Abstract
The effects of Corynebacterium parvum suspension on the immune response of mice to tetanus toxoid were examined using toxin challenges and passive hemagglutination. The responses measured by toxin challenge were reduced as a result of the administration of C. parvum under all the circumstances investigated.
The effects of C. parvum on the antibody response, as measured by passive hemagglutination, were more varied. When given with, or before, a single dose of toxoid, C. parvum caused a slight increase in the response seen at 7 days and a slight decrease in the response seen at 21 days after the administration of the toxoid.
When given with, or before, the first of two doses of toxoid, C. parvum reduced the titer measurable 14 days after the second dose, but increased the titer if given with, or before, the second dose of toxoid. The treatment of hemagglutination assays with 2-mercaptoethanol did not materially alter the pattern of effects produced by C. parvum.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adlam, C., Broughton, E. S., and Scott, M. T. (1973). Enhanced resistance of mice following pretreatment with Corynebacterium parvum. Nat. New Biol. 235: 219.
Castro, J. E. (1973). Symposium on Immunopotentiation,p. 116, Ciba Symposium Series 19.
Fulthorpe, A. J. (1962). Multiple diphtheria antigen—antibody systems investigated by passive-hemagglutination techniques and other methods. Immunology 5: 30–45.
Gall, D. (1972). Adjuvants and different immune systems. Report and Proceedings of Alhydrogel Symposium on Vaccine Adjuvants, London, 1971. Superfos, Copenhagen.
Halpern, B. N., Biozzi, G., Stiffel, C., and Mouton, D. (1966). Inhibition of tumor growth by administration of killed Corynebacterium parvum. Nature (Lond.) 212: 853.
Neveu, T., Bronellec, A., and Biozzi, G. (1964). Propriétés adjuvantes de Corynebacterium parvum sur la production d’anticorps et sur l’induction de l’hypersensibilité retardee envers les protéines conjugées. Ann. Inst. Pasteur, Paris 106: 771–777.
Scott, M. T. (1972). Biological effects of the adjuvant Corynebacterium parvum. I. Inhibi- tion of PHA, mixed lymphocyte, and G.V.H. reactivity. Cell Immunol. 5: 459–468.
Sheffield, F. and Perkins, F. T. (1967). The response of guinea pigs to the diphtheria toxoid component of combined antigens of different formulations. Int. Symp. Combined Vaccines Marburg/L Symp. Ser. Immunobiol. Standard 7:121. Karger, Basel.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Knight, P.A., Lucken, R.N. (1975). The Effects of Corynebacterium parvum Suspension on the Response to Tetanus Toxoid. In: Halpern, B. (eds) Corynebacterium Parvum. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4428-5_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4428-5_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4430-8
Online ISBN: 978-1-4613-4428-5
eBook Packages: Springer Book Archive