Results Obtained in Our Adjuvant Screening Model with Corynebacterium parvum and Corynebacterium granulosum
Corynebacterium parvum and three preparations of Corynebacterium granulosum have been shown by one or several previous experiments to be able to stimulate immune responses. These agents were submitted to a screening battery, the object of which was to detect “systemic adjuvants of immunity” useful in cancer immunotherapy. The tests of this battery are: (a) the hemolytic plaque-forming cell test (Jerne), which produces an immune reaction requiring thymus derived and bone marrow-derived lymphocyte cooperation; (b) the graft-versushost reaction which produces an immune reaction involving only thymus-derived lymphocytes; and (c) the immunoprophylaxis of three murine tumors, a leukemia (L1210), and two solid tumors (Lewis’ tumor and ICIG CI1).
KeywordsCancer Immunotherapy Previous Experimental Research Systemic Adjuvant Corynebacterium Parvum Leukemia Mortality
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