Results Obtained in Our Adjuvant Screening Model with Corynebacterium parvum and Corynebacterium granulosum

  • G. Mathé
  • Olga Halle-Pannenko
  • J. L. Amiel

Abstract

Corynebacterium parvum and three preparations of Corynebacterium granu­losum have been shown by one or several previous experiments to be able to stimulate immune responses. These agents were submitted to a screening battery, the object of which was to detect “systemic adjuvants of immunity” useful in cancer immunotherapy. The tests of this battery are: (a) the hemolytic plaque-forming cell test (Jerne), which produces an immune reaction requiring thymus derived and bone marrow-derived lymphocyte cooperation; (b) the graft-versus­host reaction which produces an immune reaction involving only thymus-derived lymphocytes; and (c) the immunoprophylaxis of three murine tumors, a leu­kemia (L1210), and two solid tumors (Lewis’ tumor and ICIG CI1).

Keywords

Phenol Depression Leukemia Bacillus Corynebacterium 

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • G. Mathé
    • 1
  • Olga Halle-Pannenko
    • 1
  • J. L. Amiel
    • 1
  1. 1.Institut de Cancérologie et d’ImmunogénétiqueINSERM et Association Claude-Bernard, Hôpital Paul-BrousseVillejuifFrance

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