Effect of Inactivated Corynebacterium on Different Experimental Tumors in Mice

  • M. Roumiantzeff
  • M. Musetescu
  • G. Ayme
  • M. C. Mynard


The immunostimulant activities of inactivated Corynebacterium parvum suspension are well described in the work of Halpern et al. (1963). We investigated this nonspecific immunostimulation by measuring the effect of C. parvum on RES-organs stimulation, humoral-adjuvant activity, carbon-clearance stimulation, interferon induction, and protection versus bacterial and viral challenges. All these tests are quantitative and accurate enough to check experimental production precisely, judge different parameters, and control the batches used for animal or clinical trials.


Survival Time Protective Activity Tumor System Control Challenge Mean Survival Time 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • M. Roumiantzeff
    • 1
  • M. Musetescu
    • 1
  • G. Ayme
    • 1
  • M. C. Mynard
    • 1
  1. 1.Institut Français d’ImmunologieFondation Mérieux, Marcy l’EtoileCharbonnières-les-BainsFrance

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