Abstract
Studies of the potentially therapeutically useful biological effects of the anaerobic coryneform bacteria have centered on the ability of these organisms to protect the whole animal against tumors or infections and on their ability to act as immunological adjuvants. It has become apparent that these properties of anaerobic coryneform bacteria depend largely on their ability to stimulate the functions of cells of the mononuclear phagocyte system. However, whole animal models can only give limited information about the steps involved. Therefore, in this paper I wish to describe studies of the direct and immediate effects of these bacteria on mononuclear phagocytes in vitro.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boyden, S. V. (1962). The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J. Exp. Med. 115: 453.
Halpern, B. N., Prévot, A. R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J. C., Bouthillier, Y., and Decreusefond, C. (1964). Stimulation de l’activité phagocytaire du système réticuloendothéliale provoquée par Corynebacterium parvum. J. Reticuloendothel. Soc. 1: 77.
Huxley, H. E. (1973). Muscular contraction and cell motility. Nature (Gond.) 243:445.
Johnson, J. L. and Cummins, C. W. (1972). Cell-wall compositions and deoxyribonucleic acid similarities among the anaerobic coryneforms, classical propionibacteria and strains of Arachnia propionica. J. Bacteriol. 109: 1047.
McBride, W. H., Weir, D. M., Kay, A. B., Pearce, D., and Caldwell, J. R. (1975). Activation of the classical and alternate pathways of complement by Corynebacterium parvum. Clin. Exp. Immunol. 19: 143.
O’Neill, G. J., Henderson, D. C., and White, R. G. (1973). Role of anaerobic coryneforms in specific and nonspecific immunological reactions. I. Effect on particle clearance and humoral and cell-mediated immune responses. Immunology 24: 977.
Spector, W. G. and Ryan, G. B. (1970). The mononuclear phagocyte in inflammation. In: Mononuclear Phagocytes, p. 219, ( R. van Furth, ed.), Blackwell, Oxford and Edinburgh.
Symon, D. N. K., McKay, I. C., and Wilkinson, P. C. (1972). Plasma-dependent chemotaxis of macrophages towards Mycobacterium tuberculosis and other organisms. Immunology 22: 267.
White, R. G., O’Neill, G. J., Henderson, D. C., Cater, J., and Wilkinson, P. C. (1973). The adjuvant activity of “Corynebacterium parvum” in specific and nonspecific immunity. In: Nonspecific Factors Influencing Host Resistance, p. 285 ( W. Braun and J. Ungar, eds.), Karger, Basel.
Wilkinson, P. C. (1973). Recognition of protein structure in leukocyte chemotaxis. Nature (Lond.) 244: 512.
Wilkinson, P. C. (1974a). Chemotaxis and Inflammation, Churchill-Livingstone, Edinburgh.
Wilkinson, P. C. (1974b). Surface and cell-membrane activities of leukocyte chemotactic factors. Nature (Lond.) 251: 58.
Wilkinson, P. C. and McKay, I. C. (1971). The chemotactic activity of native and denatured serum albumin. Int. Arch. Allergy Appl. Immunol. 41: 237.
Wilkinson, P. C. and McKay, I. C. (1972). The molecular requirements for chemotactic attraction of leukocytes by proteins. Studies of proteins with synthetic side groups. Eur. J. Immunol. 2: 570.
Wilkinson, P. C., O’Neill, G. J., Mclnroy, R. J., Cater, J. C., and Roberts, J. A. (1973a). Chemotaxis of macrophages: the role of a macrophage-specific cytotaxin from anaerobic corynebacteria and its relation to immunopotentiation in vivo. In: Immunopotentiation, p. 121 ( G. E. Wolstenholme and J. Knight, eds.), Associated Scientific Publishers, Amsterdam.
Wilkinson, P. C., O’Neill, G. J., and Wapshaw, K. G. (1973b). Role of anaerobic coryneforms in specific and nonspecific immunological reactions. II. Production of a chemotactic factor specific for macrophages. Immunology 24: 997.
Zigmond, S. H. and Hirsch, J. G. (1973). Leukocyte locomotion and chemotaxis. New methods for evaluation and demonstration of cell-derived chemotactic factor. J. Exp. Med. 137: 387.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Wilkinson, P.C. (1975). Macrophage-Stimulating Effects of Anaerobic Coryneform Bacteria in Vitro . In: Halpern, B. (eds) Corynebacterium Parvum. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4428-5_18
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4428-5_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4430-8
Online ISBN: 978-1-4613-4428-5
eBook Packages: Springer Book Archive