Abstract
Lymph-borne immunoblasts were obtained by collecting thoracic duct lymph from rats stimulated antigenically with Corynebacterium parvum, BCG and Brucella abortus. The immunoblasts were labeled by in vitro incubation with [125I] -UDR. After being washed, they were injected intravenously into syngenic rats. These recipients had received intradermal injections of various antigens a few days previous to immunoblast injection. The entry of the labeled immunoblasts into these intradermal injection sites was monitored by counting the radioactivity that accumulated in the sites 24 h after injection.
It was found that only the cutaneous sites of injection of BCG or C. parvum attracted significant numbers of immunoblasts and that the immunological specificity of the injected cells played no demonstrable role in guiding them to their destination. It was concluded that local injections of C. parvum or BCG bring about a change in the local capillaries that causes lymphoid cells to extravasate in increased numbers.
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© 1975 Plenum Press, New York
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Hall, J.G., Moore, A.R. (1975). The Action of Local Injections of Corynebacterium parvum in Facilitating the Extravasation of Activated Lymphoid Cells. In: Halpern, B. (eds) Corynebacterium Parvum. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4428-5_11
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DOI: https://doi.org/10.1007/978-1-4613-4428-5_11
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