Suppression by Soluble Factor Released from B Cells
Whereas suppression of immune responses by T cells has been well documented (1), the role played by B cells in the regulation of the immune response is less well known. The mouse bone marrow contains a radiosensitive, non-T, non-macrophage cell population which dramatically suppresses the primary and secondary IgM PFC response of spleen cells both in vivo and in vitro (2–4). In this communication we will present evidence for the release of suppressive and augmenting materials from cells in the bone marrow and attempt to clarify the target and mechanism of action of the suppressor cell.
KeywordsBone Marrow Cell Spleen Cell Suppressor Cell Suppressive Activity Mouse Bone Marrow
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- 1.Gershon, R.K., Orbach-Arbouys, S., and Calkins, C. Prog. Immunology 2: 122, 1974.Google Scholar
- 4.Singhal, S.K. and Duwe, A.K. In Suppressor Cells In Immunity, edited by S.K. Singhal and N.R. Sinclair, University of Western Ontario Press, London, Canada, 1975.Google Scholar
- 11.Veit, B., and Michael, J.G. J. Immunol. Ill: 341, 1973.Google Scholar
- 12.Nossal, G.J.V. and Pike, B.L. J. Exp. Med. 141: 904, 1975.Google Scholar