Suppression by Soluble Factor Released from B Cells

  • A. K. Duwe
  • S. K. Singhal


Whereas suppression of immune responses by T cells has been well documented (1), the role played by B cells in the regulation of the immune response is less well known. The mouse bone marrow contains a radiosensitive, non-T, non-macrophage cell population which dramatically suppresses the primary and secondary IgM PFC response of spleen cells both in vivo and in vitro (2–4). In this communication we will present evidence for the release of suppressive and augmenting materials from cells in the bone marrow and attempt to clarify the target and mechanism of action of the suppressor cell.


Bone Marrow Cell Spleen Cell Suppressor Cell Suppressive Activity Mouse Bone Marrow 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. K. Duwe
    • 1
  • S. K. Singhal
    • 1
  1. 1.Department of Bacteriology and ImmunologyUniversity of Western OntarioLondonCanada

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