Host Protection by the Antibody-Forming System in Malignancy
We have previously reported, that not only impairment of cell-mediated immunity, but also impairment of bursa dependent, anti-body-producing capacity decreases host defense to tumors induced by the avian reticuloendotheliosis (RE) virus, strain T, indicating that both parts of the immune system have a host-protective function in this malignancy(1, 2). In order to study whether the antibody-forming system may have a host-protective function in oncogenesis in general, unrelated tumors were studied with regard to tumor development in bursectomized and control animals. The tumors chosen for this purpose were tumors induced by XC cells, a Rous sarcoma-derived tumor line, and a chemical carcinogen-induced transplantable fibrosarcoma. The three malignancies chosen for study are of widely different genesis, and convergent results could therefore illustrate a common principle in host defense in oncogenesis.
KeywordsSarcoma Cyclophosphamide Pyrene Fibrosarcoma Trioctanoin
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