Abstract
Reappearance of immunological responsiveness after lethal irradiation and reconstitution with hemopoietic stem cells is dependent on the recovery of two types of lymphoid cells: B and T cells. The B cell compartment seems to recover faster than the T cell compartment (1, 2). Nossal and Pike compared the rate of recovery of anti-immunoglobulin binding cells in different lymphoid organs. They found a somewhat faster repopulation in the spleen than in lymph nodes and bone marrow (3, 4). Everett and Tyler (5) provided evidence that in normal mice the marrow is the major site of lymphocyte production. These lymphocytes are probably immature stages of the B cell line (6).
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© 1976 Plenum Press, New York
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Rozing, J., Benner, R. (1976). The Recovery of the B Cell Compartment in Lethally Irradiated and Reconstituted Mice. In: Feldman, M., Globerson, A. (eds) Immune Reactivity of Lymphocytes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4355-4_31
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DOI: https://doi.org/10.1007/978-1-4613-4355-4_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4357-8
Online ISBN: 978-1-4613-4355-4
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