Abstract
The central role played by the thymus during leukemogenesis in the AKR mouse is well established (1, 2). The AKR mouse develops lymphocytic lymphoma and leukemia with an incidence of 90% (2). Although this strain is infected with gross virus prior to birth, manifestations of the disease are not apparent until six months of age (3). Therefore, there appears to be a latent period before the onset of thymoma in these animals. The intrathymic events during this latent period are of prime importance since neonatal thymectomy reduces the incidence of leukemia (4).
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© 1976 Plenum Press, New York
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Waksal, S.D., Smolinsky, S., Cohen, I.R., St. Pierre, R.L., Feldman, M. (1976). Thymocyte Maturation in AKR Leukemia. In: Feldman, M., Globerson, A. (eds) Immune Reactivity of Lymphocytes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4355-4_21
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DOI: https://doi.org/10.1007/978-1-4613-4355-4_21
Publisher Name: Springer, Boston, MA
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