Experiments and Theoretical Considerations on Synchronisation of L 1210 Ascites Tumour Cells and Crypt Epithelia of the Mouse with Vincristine
The chemotherapy of malignant tumours is limited as many drugs are most effective against cells in one specific phase of the cell cycle. If by synchronisation the number of cells in the drug sensitive phase could be increased the chances of successful therapy would be improved. Such a cycle phase specific therapy after synchronisation is often practiced clinically using Vincristine in combination with cyclophosphamide. With this form of therapy the most important question is if it is possible to achieve in vivo synchronisation of cells.
KeywordsCycle Time Labelling Index Normal Mouse Mitotic Index Specific Phase
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