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Experiments and Theoretical Considerations on Synchronisation of L 1210 Ascites Tumour Cells and Crypt Epithelia of the Mouse with Vincristine

  • W. Jellinghaus
  • R. Maidhof
  • B. Schultze
  • W. Maurer
Part of the Chemotherapy book series (CT, volume 8)

Abstract

The chemotherapy of malignant tumours is limited as many drugs are most effective against cells in one specific phase of the cell cycle. If by synchronisation the number of cells in the drug sensitive phase could be increased the chances of successful therapy would be improved. Such a cycle phase specific therapy after synchronisation is often practiced clinically using Vincristine in combination with cyclophosphamide. With this form of therapy the most important question is if it is possible to achieve in vivo synchronisation of cells.

Keywords

Cycle Time Labelling Index Normal Mouse Mitotic Index Specific Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. Jellinghaus
    • 1
  • R. Maidhof
    • 1
  • B. Schultze
    • 1
  • W. Maurer
    • 1
  1. 1.Institut für Medizinische StrahlenkundeUniversität Würzburg87 WürzburgWest-Germany

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