Studies of N-Methyl-N-Nitrosourea-C14O Pharmacokinetics in Mice with Hepatoma 22A
The appearance of the carbonyl label in target molecules of liver, spleen, kidney, GI mucosa and hepatoma 22a was studied after a single injection of MNU-C14O in a therapeutic dose (80 mg/kg). A high proportion of radioactivity was found in the protein and lipid fractions. The carbonyl label was found in RNA of all organs only 1–5 hours after MNU-C14 administration. The radioactivity detected in proteins and lipids after MNU-C14O administration is retained in hepatoma cells for longer periods of time (72 hours) while it is rapidly eliminated from normal cells.
KeywordsHodgkin1s Disease Single Injection Lipid Fraction Total Radioactivity Lewis Lung Carcinoma
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