Chemotherapy pp 209-213 | Cite as

Studies of N-Methyl-N-Nitrosourea-C14O Pharmacokinetics in Mice with Hepatoma 22A

  • L. B. Gorbacheva
  • G. V. Kukushkina
  • I. S. Sokolova
  • A. M. Serebryanyi
  • V. S. Tutlyte
Part of the Chemotherapy book series (CT, volume 8)

Summary

The appearance of the carbonyl label in target molecules of liver, spleen, kidney, GI mucosa and hepatoma 22a was studied after a single injection of MNU-C14O in a therapeutic dose (80 mg/kg). A high proportion of radioactivity was found in the protein and lipid fractions. The carbonyl label was found in RNA of all organs only 1–5 hours after MNU-C14 administration. The radioactivity detected in proteins and lipids after MNU-C14O administration is retained in hepatoma cells for longer periods of time (72 hours) while it is rapidly eliminated from normal cells.

Keywords

Toxicity Lymphoma Carbonyl Macromolecule Rosen 

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • L. B. Gorbacheva
    • 1
  • G. V. Kukushkina
    • 1
  • I. S. Sokolova
    • 1
  • A. M. Serebryanyi
    • 1
  • V. S. Tutlyte
    • 1
  1. 1.Institute of Chemical PhysicsAcademy of ScienceMoscowUSSR

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