Studies of N-Methyl-N-Nitrosourea-C14O Pharmacokinetics in Mice with Hepatoma 22A
The appearance of the carbonyl label in target molecules of liver, spleen, kidney, GI mucosa and hepatoma 22a was studied after a single injection of MNU-C14O in a therapeutic dose (80 mg/kg). A high proportion of radioactivity was found in the protein and lipid fractions. The carbonyl label was found in RNA of all organs only 1–5 hours after MNU-C14 administration. The radioactivity detected in proteins and lipids after MNU-C14O administration is retained in hepatoma cells for longer periods of time (72 hours) while it is rapidly eliminated from normal cells.
KeywordsToxicity Lymphoma Carbonyl Macromolecule Rosen
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