Chemotherapy pp 153-158 | Cite as

The Effect of Dibromodulcitol on the Replication of DNA in Yoshida Sarcoma Cells

  • Etel Institoris
  • L. Holczinger
Part of the Chemotherapy book series (CT, volume 8)


Doses of dibromodulcitol uhich significantly suppressed the grouth rate of Yoshida sarcoma cells in culture produce an alkylation level of 2.3 – 4.3 x 105 nucleotides per molecule of dibromodulcitol in DNA. This extent of alkylation does not lead to single strand breaks in the parental DNA, whereas it causes postreplicative lesions in the neuly synthesized DNA strand, the repair of uhich is dose dependent.


Single Strand Break Sedimentation Profile Chase Experiment Sedimentation Figure Daughter Strand 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Etel Institoris
    • 1
  • L. Holczinger
    • 1
  1. 1.Research Institute of OncopathologyBudapestHungary

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