Alterations in Intracellular Cyclic AMP as a Potential Form of Anti-Tumour Chemotherapy

  • M. J. Tisdale
  • B. J. Phillips


The possibility of using cyclic AMP either as an inhibitor of cell proliferation, or to facilitate the reversal of the abnormally differentiated state of neoplastic tumours has been considered. The parameters involved in regulation of intracellular levels of cyclic AMP have been defined. The anti-tumour akylating agents have been given as an example of tumour growthinhibitors the mechanism of action of which may involve cyclic AMP.


Intracellular Level Cyclic Nucleotide Cyclic Nucleotide Phosphodiesterase Walker Cell Fold Resistance 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. J. Tisdale
    • 1
    • 2
  • B. J. Phillips
    • 1
    • 2
  1. 1.Department of BiochemistrySt. Thomas’s Hospital Medical SchoolLondonUK
  2. 2.Chester Beatty Research InstituteLondonUK

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