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Alterations in Intracellular Cyclic AMP as a Potential Form of Anti-Tumour Chemotherapy

  • M. J. Tisdale
  • B. J. Phillips

Summary

The possibility of using cyclic AMP either as an inhibitor of cell proliferation, or to facilitate the reversal of the abnormally differentiated state of neoplastic tumours has been considered. The parameters involved in regulation of intracellular levels of cyclic AMP have been defined. The anti-tumour akylating agents have been given as an example of tumour growthinhibitors the mechanism of action of which may involve cyclic AMP.

Keywords

Intracellular Level Cyclic Nucleotide Cyclic Nucleotide Phosphodiesterase Walker Cell Fold Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. J. Tisdale
    • 1
    • 2
  • B. J. Phillips
    • 1
    • 2
  1. 1.Department of BiochemistrySt. Thomas’s Hospital Medical SchoolLondonUK
  2. 2.Chester Beatty Research InstituteLondonUK

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