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Chemotherapy pp 355-358 | Cite as

Radiotherapy and Chemotherapy in Acute Leukaemia Related to Fatal Infection During Remission

  • I.C.M. MacLennan on behalf of the British Medical Research Council’s Working Party on Leukaemia in Childhood

Abstract

There has been steady improvement in the survival of patients with acute lymphoblastic leukaemia over the past twenty years. This has mainly been due to the use of multiple drug maintenance chemotherapy given over a prolonged period and effective prevention of central nervous system (CNS) relapse. Pinkel and his group in Memphis made the break-through in prophylaxis against CNS leukaemia by the introduction of cranio-spinal irradiation(Pinkel et al, 1971). Subsequently, the British Medical Research Council carried out a trial of CNS irradiation (UKALL I) and confirmed the Memphis observations (MRC Leukaemia Committee Report, 1973). In this trial only one out of 75 patients who received CNS prophylaxis relapsed from CNS leukaemia while 26 out of 80 patients in the control group developed this complication. There was, however, a price to pay for this prophylactic treatment in that five of the CNS irradiation group died in complete remission while no remission deaths occurred in the non-irradiated group.

Keywords

British Medical Journal Maintenance Chemotherapy Pyogenic Infection British Medical Research Council Medical Research Council Working Party 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. CAMPBELL, A.C. et al (1973). British Medical Journal 2, 385.PubMedCrossRefGoogle Scholar
  2. MEDICAL RESEARCH COUNCIL (1973). British Medical Journal 2, 381.CrossRefGoogle Scholar
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  4. MEDICAL RESEARCH COUNCIL WORKING PARTY REPORT (1975b) Submitted.Google Scholar
  5. PINKEL, D. et al (1971). Cancer 27. 247.PubMedCrossRefGoogle Scholar
  6. VOGLER, W.R. et al (1973). Cancer Research 33, 1628.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • I.C.M. MacLennan on behalf of the British Medical Research Council’s Working Party on Leukaemia in Childhood
    • 1
  1. 1.Nuffield Department of Clinical MedicineRadcliffe InfirmaryOxfordEngland

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