An Experimental Approach to Increase Selective Tumour Toxicity of Methotrexate
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Thymidine protects mice bearing leukaemia L1210 and P388 from methotrexate toxicity without impairing antitumour activity. When thymidine containing pellets were implanted subcutaneously in L1210 leukaemia hearing mice, the therapeutic dose range of methotrexate was increased three-fold. The toxic effects of methotrexate in mice may be ascribed to a disturbance of de novo thymidylate synthesis but the antitumour activity must be due to a disturbance of some other folate dependent pathway.
KeywordsAnti Tumour Activity Folinic Acid Antitumour Activity Purine Biosynthesis L1210 Leukaemia
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