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In Vitro Screening of Cytotoxic Substances Using Different Tumour Cells

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Chemotherapy

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Summary

A three-step system for the screening of potential cytostatics was devised. In vitro criteria used in the first two steps of the screening allow the finding of general cytotoxic substances and to choose from them for final evaluation in vivo those in which the specific effects on tumour cells were observed. The results achieved in this system are demonstrated on the PSX-1 antibiotic.

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References

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Author information

Authors and Affiliations

  1. Department of Microbiology and Biochemistry, Slovak Polytechnical University, Bratislava, Czechoslovakia

    J. Fuska, P. Vesely, L. Ivanickaja & A. Fuskova

  2. Institute of Experimental Biology and Genetics, Prague, Czech Republic

    P. Vesely

  3. Institute of New Antibiotics, Moscow, USSR

    L. Ivanickaja

Authors
  1. J. Fuska
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  2. P. Vesely
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  3. L. Ivanickaja
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  4. A. Fuskova
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Editor information

Editors and Affiliations

  1. Westminster Hospital and Imperial Cancer Research Fund, UK

    K. Hellmann

  2. Chester Beatty Research Institute, UK

    T. A. Connors

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© 1976 Plenum Press, New York

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Fuska, J., Vesely, P., Ivanickaja, L., Fuskova, A. (1976). In Vitro Screening of Cytotoxic Substances Using Different Tumour Cells. In: Hellmann, K., Connors, T.A. (eds) Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4349-3_39

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  • DOI: https://doi.org/10.1007/978-1-4613-4349-3_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4351-6

  • Online ISBN: 978-1-4613-4349-3

  • eBook Packages: Springer Book Archive

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