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Chemotherapy pp 327-333 | Cite as

In Vitro Screening of Cytotoxic Substances Using Different Tumour Cells

  • J. Fuska
  • P. Vesely
  • L. Ivanickaja
  • A. Fuskova

Summary

A three-step system for the screening of potential cytostatics was devised. In vitro criteria used in the first two steps of the screening allow the finding of general cytotoxic substances and to choose from them for final evaluation in vivo those in which the specific effects on tumour cells were observed. The results achieved in this system are demonstrated on the PSX-1 antibiotic.

Keywords

Cytopathic Effect Screening System Tumour Cell Implantation Cytic Leukaemia Cytotoxic Substance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. Fuska
    • 1
  • P. Vesely
    • 1
    • 2
  • L. Ivanickaja
    • 1
    • 3
  • A. Fuskova
    • 1
  1. 1.Department of Microbiology and BiochemistrySlovak Polytechnical UniversityBratislavaCzechoslovakia
  2. 2.Institute of Experimental Biology and GeneticsPragueCzech Republic
  3. 3.Institute of New AntibioticsMoscowUSSR

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