In Vitro Mutagenesis by Anti-Cancer Drugs
- 81 Downloads
Many of the drugs commonly used in cancer chemotherapy are known to induce chromosome damage. Some of these are listed in Table 1. Over the past few years methods have been developed which permit the assay of induced mutation in somatic mammalian cells in vitroi 1. A number of known mutagens have been assayed in such systems,1 and a close correlation between lethal and mutagenic damage has been demonstrated2–4. A close relationship between chromosome damage and cell lethality has also been established,3,5 and hence a relationship between lethality, chromosome aberrations and mutation induction has been proposed6.
KeywordsChromosome Aberration Cytosine Arabinoside Chromosome Damage Recessive Autosomal Mouse Lymphoma Cell
Unable to display preview. Download preview PDF.
- 1).THOMPSON, L.H. and BAKER, R.M. Methods in Cell Biology VI Ch. 7 (1975) p.209–277.Google Scholar
- 2).FOX, M. Mutation Res. 29 (1975) in press.Google Scholar
- 3).ROBERTS, J.J. and STURROCK, J.E. Mutation Res. 20 (1975) 243–255.Google Scholar
- 6).ROBERTS, J.J., STURROCK, J.E. and WARD, K.N. in Chemical Carcinogenesis. P. Opts’o and J.A. Dipaulo (eds) Marcel Decker New York (1974).Google Scholar
- 7).BRUCE, W.R., MEEKER, B.E. and VALERIOTE, F.A. J.Nat.Canc.Inst. 37 (1966) 233–245.Google Scholar
- 8).ROBERTS, J.J., BRENT, T.P. and CRATHORN, A.R. p.5–27 in The interaction of drugs and subcellular components in animal cells. J.A. Churchill Limited London (1968).Google Scholar
- 10).PRUSOFF, W.H. p.45–68 in The interaction of drugs and sub-cellular components in animal cells. J.A. Churchill Limited London (1968).Google Scholar
- 12).HARTMAN, K.U. and HEIDEBERGER, C. J.Biol.Chem. 236 (1962) 3006–3013.Google Scholar
- 14).OCKEY, C.H., HSU, T.C. and RICHARDSON, L.C. J.Nat.Canc.Inst. 40 (1968) 465–475.Google Scholar
- 17).FOX, M. and BOYLE, J.M. Mutation Res. (1973) in press.Google Scholar