Chemotherapy pp 315-322 | Cite as

In Vitro Mutagenesis by Anti-Cancer Drugs

  • Margaret Fox


Many of the drugs commonly used in cancer chemotherapy are known to induce chromosome damage. Some of these are listed in Table 1. Over the past few years methods have been developed which permit the assay of induced mutation in somatic mammalian cells in vitroi 1. A number of known mutagens have been assayed in such systems,1 and a close correlation between lethal and mutagenic damage has been demonstrated2–4. A close relationship between chromosome damage and cell lethality has also been established,3,5 and hence a relationship between lethality, chromosome aberrations and mutation induction has been proposed6.


Chromosome Aberration Cytosine Arabinoside Chromosome Damage Recessive Autosomal Mouse Lymphoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    THOMPSON, L.H. and BAKER, R.M. Methods in Cell Biology VI Ch. 7 (1975) p.209–277.Google Scholar
  2. 2).
    FOX, M. Mutation Res. 29 (1975) in press.Google Scholar
  3. 3).
    ROBERTS, J.J. and STURROCK, J.E. Mutation Res. 20 (1975) 243–255.Google Scholar
  4. 4).
    DUNCAN, M. and BROOKES, P. Mutation Res. 21 (1973) 107–118.PubMedCrossRefGoogle Scholar
  5. 5).
    SCOTT, D., FOX, M. and FOX, B.W. Mutation Res. 22 (1974) 207–221.PubMedCrossRefGoogle Scholar
  6. 6).
    ROBERTS, J.J., STURROCK, J.E. and WARD, K.N. in Chemical Carcinogenesis. P. Opts’o and J.A. Dipaulo (eds) Marcel Decker New York (1974).Google Scholar
  7. 7).
    BRUCE, W.R., MEEKER, B.E. and VALERIOTE, F.A. J.Nat.Canc.Inst. 37 (1966) 233–245.Google Scholar
  8. 8).
    ROBERTS, J.J., BRENT, T.P. and CRATHORN, A.R. p.5–27 in The interaction of drugs and subcellular components in animal cells. J.A. Churchill Limited London (1968).Google Scholar
  9. 9).
    FOX, M. and FOX, B.W. Mutation Res. 19 (1973) 119–128.PubMedCrossRefGoogle Scholar
  10. 10).
    PRUSOFF, W.H. p.45–68 in The interaction of drugs and sub-cellular components in animal cells. J.A. Churchill Limited London (1968).Google Scholar
  11. 11).
    LePAGE, G.A. and JONES, M. Cancer Res. 21 (1961) 1590–1594.PubMedGoogle Scholar
  12. 12).
    HARTMAN, K.U. and HEIDEBERGER, C. J.Biol.Chem. 236 (1962) 3006–3013.Google Scholar
  13. 13).
    BERTINO, J.R. Cancer Res. 23 (1963) 1286–1306.PubMedGoogle Scholar
  14. 14).
    OCKEY, C.H., HSU, T.C. and RICHARDSON, L.C. J.Nat.Canc.Inst. 40 (1968) 465–475.Google Scholar
  15. 15).
    DeMARS, R. Mutation Res. 24 (1974) 335–364.PubMedCrossRefGoogle Scholar
  16. 16).
    BEAUDET, A.L., ROUFA, D.A. and CASKEY, C.T. Proc.Nat.Acad.Sci. (US) 70 (1973) 320–324.CrossRefGoogle Scholar
  17. 17).
    FOX, M. and BOYLE, J.M. Mutation Res. (1973) in press.Google Scholar
  18. 18).
    ANDERSON, D. and FOX, M. Mutation Res. 23 (1974) 107–122.CrossRefGoogle Scholar
  19. 19).
    HUBERMAN, E. and HEIDEBERGER, C. Mutation Res. 14 (1972) 130–132.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Margaret Fox
    • 1
  1. 1.Paterson LaboratoriesChristie Hospital & Holt Radium InstituteManchesterUK

Personalised recommendations