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Attempts to Overcome Methotrexate Resistance: The Value of Drug Resistant Cell Lines

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Chemotherapy

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Abstract

The potential antitumour effects of chemotherapy agents frequently are assessed in vitro and/or in vivo using experimental test systems consisting of tumour cells which show an inherent sensitivity to cytotoxic drugs (1–3). Since a major problem in cancer chemotherapy is that of drug resistance, there is a need to select agents effective against cells resistant to currently-available drugs. One approach, which has received little attention, is to use drug-resistant cells in culture.

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Author information

Authors and Affiliations

  1. Imperial Cancer Research Fund, London, UK

    Bridget T. Hill

  2. Institute of Cancer Research, London, UK

    L. A. Price

  3. St. Michael’s Hospital, Toronto, Canada

    J. H. Goldie

Authors
  1. Bridget T. Hill
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  2. L. A. Price
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  3. J. H. Goldie
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Editor information

Editors and Affiliations

  1. Westminster Hospital and Imperial Cancer Research Fund, UK

    K. Hellmann

  2. Chester Beatty Research Institute, UK

    T. A. Connors

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© 1976 Plenum Press, New York

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Hill, B.T., Price, L.A., Goldie, J.H. (1976). Attempts to Overcome Methotrexate Resistance: The Value of Drug Resistant Cell Lines. In: Hellmann, K., Connors, T.A. (eds) Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4349-3_36

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  • DOI: https://doi.org/10.1007/978-1-4613-4349-3_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4351-6

  • Online ISBN: 978-1-4613-4349-3

  • eBook Packages: Springer Book Archive

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