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Chemotherapy pp 299-302 | Cite as

Recent Experience with Microbial Systems and Cancer Cells in Vitro in the Screening for Antitumor Antibiotics

  • G. F. Gause

Summary

New mutants of E. coli with altered cytoplasmic membrane and increased permeability have been profitably employed for the detection of new antimetabolites synthesized by microorganisms. Mitochondrial mutants of yeast also represent considerable interest in the screening for new antimetabolites synthesized by actinomycetes, since they can detect products which remain unnoticed with the aid of many other tests. Ascites tumor cells, after numerous alternating passages through the primary culture in the test tube and through the abdominal cavity of mice, are also useful in the screening of antitumor antibiotics.

Keywords

Test Tube Minal Cavity Cell Wall Biosynthesis Microbial System Microbiological Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bibikova, M.V., Laiko, A.V., Selezneva, T.I. and Terecnova, L.P. (1973), Antibiotika., 18, 1074Google Scholar
  2. Gause, G.F., Laiko, A.V., Kusovkova, L.I. and Selesneva, T.I. (1972), Antibiotiki; 17, 195PubMedGoogle Scholar
  3. Hanka, L.J. (1972), Advances Applied Microbiol., 15, 147CrossRefGoogle Scholar
  4. Makukho, L.V., Ivanitskaya, L.P. and Volkova, L.Y. (1972) Antibiotiki, 17, 117PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • G. F. Gause
    • 1
  1. 1.Institute of New AntibioticsAcademy of Medical SciencesMoscowUSSR

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