New Leads Towards Antitumor Selectivity in Therapeutics
Four approaches to cancer chemotherapy currently being studied in this Department are discussed: 1) correlations between nucleotide pools in target tumor cells and selective activity of drugs; 2) reversal by a hormone of the host toxicity of an antitumor agent; 3) potential interference with cell division by uses of cyclic nucleotide analogs; and 4) increased antigenicity of leukemic lines resistant to certain drugs.
KeywordsL1210 Cell Nucleotide Pool Intestinal Toxicity IPAR Treatment Host Toxicity
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