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New Leads Towards Antitumor Selectivity in Therapeutics

  • Enrico Mihich

Summary

Four approaches to cancer chemotherapy currently being studied in this Department are discussed: 1) correlations between nucleotide pools in target tumor cells and selective activity of drugs; 2) reversal by a hormone of the host toxicity of an antitumor agent; 3) potential interference with cell division by uses of cyclic nucleotide analogs; and 4) increased antigenicity of leukemic lines resistant to certain drugs.

Keywords

L1210 Cell Nucleotide Pool Intestinal Toxicity IPAR Treatment Host Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bloch, A. (1974). Biochem. Biophys. Research Communications, 58, 652.CrossRefGoogle Scholar
  2. Bloch, A. (1975). In Adv. Cyclic Nucleotide Research, G.I. Drummond, P. Greengard and G.A. Robison, eds., Raven Press, New York, 5, 331.Google Scholar
  3. Bloch, A., Dutschman, G., Grindey, G., and Simpson, C.L. (1974). Cancer Research 34, 1299.PubMedGoogle Scholar
  4. Bloch, A., Hromchak, R., and Henderson, E.S. (1975). Proc. Am. Assoc. Cancer Research 16, 191.Google Scholar
  5. Brockman, R.W., Shaddix, S.C., Williams, M., Nelson, J.A., Rose, L.M., and Schabel, F.M. Jr. (1975). Ann. NY Acad Sci 255, 501.PubMedCrossRefGoogle Scholar
  6. Frei, E., III, Jaffe, N., Tattersall, M.H.N., Pitman, S., and Parker, L. (1975). New England J. Medicine 292, 846.CrossRefGoogle Scholar
  7. Fuji, H. and Mihich, E. (1975). Cancer Research 35, 946.PubMedGoogle Scholar
  8. McPartland, R.P., Wang, M.C., Bloch, A., and Weinfeld, H. (1974). Cancer Research 34, 3107.PubMedGoogle Scholar
  9. Mihich, E. (1973). In Drug Resistance and Selectivity: Biochemical and Cellular Basis, E. Mihich, ed., Academic Press, New York, p. 391.Google Scholar
  10. Neil, G.L., Berger, A.E., Blowers, C.L. and Kuentzel, S.L. (1975). Proc. Am. Assoc. Cancer Research 16 114.Google Scholar
  11. Rustum, Y.M. (1975). Proc. Am. Assoc. Cancer Research 16, 191.Google Scholar
  12. Rustum, Y.M. and Schwartz, H.S. (1974). Biochem. Pharmacology 23, 2469.CrossRefGoogle Scholar
  13. Slocum, H.K. and Hakala, M.T. (1975). Cancer Research 35, 423.PubMedGoogle Scholar
  14. Wang, M.C. and Bloch, A. (1974). Biochem. Pharmacol. 21, 1063.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Enrico Mihich
    • 1
  1. 1.N.Y. State Department of HealthGrace Cancer Drug Center, Roswell Park Memorial InstituteBuffaloUSA

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