Chemotherapy pp 271-275 | Cite as

Chemotherapy of CNS Tumors

  • Michael D. Walker


The use of chemotherapy in the treatment of malignant glioma is not new. Since the earliest days of using nitrogen mustard, a few score of patients have been treated with whatever was the agent of interest at the time. The problem has always been to assess the value of these compounds which obviously have modest efficacy and an extremely low therapeutic index. These evaluations were usually carried out in patients who were seen at anytime during the course of their disease, but frequently upon recurrence and at a time when they were deteriorating. Thus, we have multiple reports within the literature which are, at best, discouraging and, at worst, inconclusive.


Malignant Glioma Bronchogenic Carcinoma Nitrogen Mustard Combine Modality Therapy Modest Efficacy 
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  1. Bennett, A.H. and Godlee, R.J. (1884) Lancet, 2, 1090.CrossRefGoogle Scholar
  2. Bouchard, J. (1966) Radiation Therapy of Tumors and Diseases of the Nervous System, Phila. Lea & Febiger, 244.Google Scholar
  3. Crivelli, G., Monfardini, S., Morello, G., and Bonadonna, G. (1974), Presented at the XIth International Cancer Congress, Florence.Google Scholar
  4. Goldsmith, M.A. (1974) Cancer Treatment Reviews, 1, 153.CrossRefGoogle Scholar
  5. Gutin, P.H., Wilson, C.B., Kumar, A.R.V., et al (1975) Cancer, 35, 1398.PubMedCrossRefGoogle Scholar
  6. Irwin, L., George, F., Pitts, F., and Davis, R. (1975) Amer. Assoc. Cancer Res. 16, 1088, p. 243.Google Scholar
  7. Shapiro, W.R. and Young, D.F. (1974) Neurology, Minn., 24, 380.Google Scholar
  8. Walker, M.D. (1973) in Cancer Medicine, edited by Holland & Frei, Philadelphia, Lea & Febiger, 1385.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Michael D. Walker
    • 1
  1. 1.Baltimore Cancer Research CenterNational Cancer InstituteBaltimoreUSA

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