Advertisement

Chemotherapy pp 243-248 | Cite as

The Biological Basis of Combination Chemotherapy

  • Abraham Goldin

Abstract

The biological rationales employed to increase antitumor specificity with combination chemotherapy are reviewed here.

Keywords

Combination Chemotherapy Antitumor Agent Cytosine Arabinoside High Total Dosage Host Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bast, R.C., Jr., Zbar, B., Borsos, T. and Rapp, H.J. (1974), New England J. Med., 290, 1413.CrossRefGoogle Scholar
  2. 2.
    Bonmassar, E., Bonmassar, A., Vadlamudi, S. and Goldin, A. (1970), Proc. Natl. Acad. Sciences, 66, 1089.CrossRefGoogle Scholar
  3. 3.
    Brockman, R.W., Shaddix, S., Laster, W.R., Jr. and Schabel, F.M., Jr., (1970a), Cancer Res., 30, 2358.PubMedGoogle Scholar
  4. 4.
    Brockman, R.W., Sidwell, R.W., Arnett, G. and Shaddix, S. (1970b), Proc. Soc. Exp. Biology, New York, 133, 609.Google Scholar
  5. 5.
    Elion, G.B., Singer, S. and Hitchings, G.H. (1954), J. Biol. Chem., 208, 477.PubMedGoogle Scholar
  6. 6.
    Fisher, J.C., Grace, W.R. and Mannick, J.A. (1970), Cancer, 26, 1379.PubMedCrossRefGoogle Scholar
  7. 7.
    Furth, J.J. and Cohen, S.S. (1968), Cancer Res., 28, 2061.PubMedGoogle Scholar
  8. 8.
    Glynn, J.B., Halpern, B.L. and Fefer, A. (1969), Cancer Res., 29, 515.PubMedGoogle Scholar
  9. 9.
    Goldin, A. (1973), Cancer Chem. Rep., 4, 189.Google Scholar
  10. 10.
    Goldin, A., Humphreys, S.R., Venditti, J.M. and Mantel, N. (1958), Ann. N.Y. Acad. Sci., 76, 932.PubMedCrossRefGoogle Scholar
  11. 11.
    Goldin, A. and Johnson, R.K. (1975), Excerpta Medica International Congress, Series No. 353, 5, Proc. XIth Int. Cancer Cong., Florence, Italy, 1974, 308.Google Scholar
  12. 12.
    Goldin, A., Venditti, J.M., Humphreys, S.R., Dennis, D. and Mantel, N. (1955), Cancer Res., 15, 742.PubMedGoogle Scholar
  13. 13.
    Goldin, A., Venditti, J.M., Mantel, N., Kline, I. and Gang, M. (1968), Cancer Res., 28, 950.PubMedGoogle Scholar
  14. 14.
    Goldin, A., Venditti, J.M. and Mantel, N. (1973), Handbook of Experimental Pharmacology, Antineoplastic and Immunosuppressive Agents, Berlin, Springer-Verlag, 411.Google Scholar
  15. 15.
    Hutchison, D.J. (1963), Advances in Cancer Research (edited by A. Haddow and S. Weinhouse), 7, 235.Google Scholar
  16. 16.
    Johnson, R.E. (1964), J. Natl. Cancer Inst., 32, 1333.PubMedGoogle Scholar
  17. 17.
    Johnson, R.K., Kline, I., Venditti, J.M. and Goldin, A. (1975), Proc. Amer. Assoc. Cancer Res., 16, 75.Google Scholar
  18. 18.
    Karrer, K., Humphreys, S.R. and Goldin, A. (1967), Internatl. J. of Cancer, 2, 213.CrossRefGoogle Scholar
  19. 19.
    Kline, I., Gang, M. and Venditti, J.M. (1972), Proc. Amer. Assoc. Cancer Res., 13, 29.Google Scholar
  20. 20.
    Kline, I., Venditti, J.M., Mead, J.A.R., Tyrer, D.D. and Goldin, A. (1966a), Cancer Res., 26, 848.PubMedGoogle Scholar
  21. 21.
    Kline, I., Venditti, J.M., Tyrer, D.D., Mantel, N. and Goldin, A. (1966b), Cancer Res., 26, 1930.PubMedGoogle Scholar
  22. 22.
    Krakoff, I.H., Brown, N.C. and Reichard, P. (1968), Cancer Res., 28, 1559.PubMedGoogle Scholar
  23. 23.
    Law, L.W., Taormina, V. and Boyle, B.J. (1954), Ann. N.Y. Acad. Sci., 60, 224.CrossRefGoogle Scholar
  24. 24.
    Mayo, J.G., Laster, W.R., Jr., Andrews, C.M. and Schabel, F.M., Jr. (1972), Cancer Chem. Rep., 56, 183.Google Scholar
  25. 25.
    Mihich, E., (1967), Proc. of the 5th International Congress of Chemotherapy, (edited by K.H. Spitzy and H. Haschek), Wiener Medizinischen Akademie, Vienna, 3, 327.Google Scholar
  26. 26.
    Nicolin, A., Vadlamudi, S. and Goldin, A. (1972), Cancer Res., 32, 653.PubMedGoogle Scholar
  27. 27.
    Pearson, J.W., Pearson, G.R., Gibson, W.T., Chermann, J.C. and Chirigos, M.A. (1972), Cancer Res., 32, 904.PubMedGoogle Scholar
  28. 28.
    Potter, V.R. (1951), Proc. Soc. Exp. Biol. Med., 76, 44.Google Scholar
  29. 29.
    Sartorelli, A.C. (1974), Biochemical Pharmacology, 23, Supplement 2, 129.Google Scholar
  30. 30.
    Sartorelli, A.C. and Booth, B.A. (1967), Cancer Res., 27, 1614.PubMedGoogle Scholar
  31. 31.
    Sartorelli, A.C., Booth, B.A. and Moore, E.C. (1969), Proc. Amer. Assoc. Cancer Res., 10, 76.Google Scholar
  32. 32.
    Sartorelli, A.C. and Creasey, W.A. (1973), Cancer Medicine, (edited by J.F. Holland and E. Frei, III), Philadelphia, Lea and Febiger, 707.Google Scholar
  33. 33.
    Schabel, F.M., Jr. (1975), Pharmacological Basis of Cancer Chemotherapy, The Williams and Wilkins Co., Baltimore, Md., 595.Google Scholar
  34. 34.
    Schabel, F.M., Jr., Laster, W.R., Jr., Trader, M.W. and Witt, M.H. (1975), Proc. Amer. Assoc, Cancer Res., 16, 24.Google Scholar
  35. 35.
    Schmidt, L.H., Montgomery, J.A., Laster, W.R., Jr. and Schabel, F.M., Jr. (1970), Proc. Amer. Assoc. Cancer Res., 11, 70.Google Scholar
  36. 36.
    Simmons, R.L. and Rios, A. (1971), Science, 174, 591.PubMedCrossRefGoogle Scholar
  37. 37.
    Straus, M.J. and Goldin, A. (1972), Cancer Chem. Rep., 56, 19.Google Scholar
  38. 38.
    Tyrer, D.D., Kline, I., Venditti, J.M. and Goldin, A. (1967), Cancer Res., 27, 873.PubMedGoogle Scholar
  39. 39.
    Vadlamudi, S. and Goldin, A. (1971), Cancer Chem. Rep., 55, 547.Google Scholar
  40. 40.
    Vadlamudi, S., Subba Reddy, V.V. and Goldin, A. (1972), Proc. Amer. Assoc. Cancer Res., 13, 31.Google Scholar
  41. 41.
    Venditti, J.M. and Goldin, A. (1964), Advances in Chemotherapy, Volume 1, Academic Press Inc., New York, 397.Google Scholar
  42. 42.
    Venditti, J.M. and Goldin, A. (1974), Biochemical Pharmacology, 23, Supplement 2, 141.Google Scholar
  43. 43.
    Venditti, J.M., Kline, I., Tyrer, D.D. and Goldin, A. (1965), Cancer Chem. Rep., 48, 35.Google Scholar
  44. 44.
    Woodman, R.J., Kline, I. and Venditti, J.M. (1972), Proc. Amer. Assoc. Cancer Res., 13, 31.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Abraham Goldin
    • 1
  1. 1.National Cancer InstituteBethesdaUSA

Personalised recommendations