The Production of Osteolytic Substances by Human Breast Tumours
Patients with cancer of the breast frequently develop abnormalities of calcium metabolism which sometimes result in death. These abnormalities are usually associated with osteolytic bone metastases and are mainly caused by excessive mobilisation of skeletal calcium. This raises the possibility that the mobilisation of skeletal calcium and erosion of bone to provide space for tumour growth may depend on the production of osteolytically active substances either by tumour cells or as a result of interactions between tumour and host cells.
KeywordsBone Erosion Human Breast Tumour Tumour Cell Injection Osteolytic Bone Metastasis Facilitate Tumour Growth
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