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Chemotherapy pp 233-238 | Cite as

Utilization of Nitrosamine-Induced Tumors as Models for Cancer Chemotherapy

  • D. Schmähl

Abstract

Chemotherapeutic studies on transplanted tumors have only little relevance for the cancer in man. The reason for this is first the biological differences between transplanted tumors and autochthonous tumours, and second, that the malignant tumors in man are of autochthonous character. It is not surprising, therefore, that positive chemotherapy findings in rats on transplanted tumors (2) first carried out in the 1950’s, were later proved to be unsuccessful when used as therapy for human cancer. It is well known that in rats and mice a great number of transplanted tumors can be cured today by various chemotherapeutic agents, whereas malignant tumors in man are mostly resistant to chemotherapy or are only partially responding. Therefore, for the last few years we have tried to use chemically-induced autochthonous tumors (predominantly in rats) in chemotherapeutic studies (1, 4, 7–12). These tumors appear to be ideal test models because most of the human tumors are also considered to be induced by chemical carcinogens (12). The following essentials are required for the use of autochthonous animal tumors in chemotherapeutic studies:
  1. a)

    the tumor must be reproducible in high yield and if possible should be developed in only one organ (unilocular occurrence);

     
  2. b)

    the tumors must occur at almost the same time in all animals (use of inbred strains);

     
  3. c)

    the tumors must be diagnosable in time;

     
  4. d)

    a chemotherapeutically untreated control, as large as possible, is particularly important.

     

Keywords

Induction Time Chemical Carcinogen Brain Glioma Oesophagus Carcinoma Autochthonous Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Brune, H., Hennıng, S., Schmähl, D. Der EinfluB von Glukokortikoiden auf das Wachstum und die chemotherapeutische BeeinfluB-barkeit autochthoner Benzpyren-Sarkome bei Mäusen Z. Krebsforschung 72, 213–218 (1969).CrossRefGoogle Scholar
  2. 2.
    Druckrey, H., Schmähl, D., Dischler, W. Endgültige Heilung groBer Yoshida-Sarkome durch N-oxyd-Lost. Dtseh. med. Wschr. 83, 489–492 (1958).CrossRefGoogle Scholar
  3. 3.
    Druckrey, H., Preussmann, R., Ivankovic, S., Schmähl, D. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nıtroso-Verbindungen an BD-Ratten. Z. Krebsforschung 69, 103–137 (1967).CrossRefGoogle Scholar
  4. 4.
    Fretz, J., Rohde, D., Schmähl, D., Thomas, C. Therapieversuche am autochthonen Mamma-Carcinom der Ratte Arzneimittelforschung 19, 1291–1293 (1969).Google Scholar
  5. 6.
    Bürkle, G. Fortschr. Röntgenstrahlen (in press).Google Scholar
  6. 5.
    Burkle, G. Möglichkeiten röntgendıagnostischer Untersuchungen und therapeutische Perspektiven bei chemisch induzierten Tumoren Fortschr. Röntgenstrahlen 122, 352–364 (1975).CrossRefGoogle Scholar
  7. 7.
    Schmähl, D., Schrick, G., König, K. Chemotherapıe-Versuche an Hepatomen. Arzneimittelforschung 13, 370–371 (1963).PubMedGoogle Scholar
  8. 8.
    Schmähl, D. Wert und Gefahr der Krebs-Chemotherapie. Dtsch. med. Wschr. 88, 1463–1468 (1963).PubMedCrossRefGoogle Scholar
  9. 9.
    Schmähl, D., Osswald, H., Brune, H. Chemotherapieversuche mit Endoxan an autochthonen Benzpyren-Sarkomen bei Ratten und Mäusen. Z. Krebsforschung 68, 293–302 (1966).CrossRefGoogle Scholar
  10. 10.
    Schmähl, D., Osswald, H., Brune, H. EınfluB von Dosıs und TumorgröBe für das Ansprechen autochthoner Benzpyren-Sarkome bei Ratten und Mäusen auf chemotherapeutische Behandlung mit Endoxan. Z. Krebsforschung 70, 246–251 (1968).CrossRefGoogle Scholar
  11. 11.
    Schmähl, D. Autochthone Tiertumoren als Testmodelle für Krebs-Chemotherapeutika. Mitteilungen der Deutschen Pharmazeutischen Gesellschaft 40, 173–175 (1970).PubMedGoogle Scholar
  12. 12.
    Schmähl, D. Entstehung, Wachstum und Chemotherapie maligner Tumoren, 2nd Edition 1970, Editio Cantor Aulendorf.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • D. Schmähl
    • 1
  1. 1.Institut für Toxikologie und Chemotherapy amDeutschen KrebsforschungszentrumHeidelbergGermany

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