Possibilities of the Human Tumour/Nude Mouse System in Cancer Chemotherapy Research
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Nude mice suffering from congenital thymus aplasia will regularly accept transplants of human malignant tumours. Tumours grow locally and metastases have not been observed. Serial growth has been obtained for up to 53 generations during a 5 year period. The human nature of these tumours is preserved as judged by microscopic appearance, chromosome analyses, isozyme patterns and demonstration of antihuman antibodies in sera of tumour bearing mice.