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Analogues and Metabolites of Cyclophosphamide

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Chemotherapy

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Abstract

In 1969 I proposed a mechanism of biological Cyclophosphamide (CYM) activation ( 18) which is shown by figure 1. This pathway was concluded from circumstantial evidence that 4-carboxy-CYM is the main CYM metabolite and the C-4 atom of the molecule ring is the preferential site of biological oxidation. I assumed that one of the metabolites should account for the tumour specific activity of the drug. This we could rule out concerning 4-carboxyCYM although this compound has been identified as the main metabolite by Struck and co-workers in addition to 4-keto-CYM, a non toxic minor metabolite (27).

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Author information

Authors and Affiliations

  1. Institute for Pneumoconiosis Research and Occupational Medicine, University of Muenster, German Federal Republic

    K. Norpoth

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  1. K. Norpoth
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Editor information

Editors and Affiliations

  1. Westminster Hospital and Imperial Cancer Research Fund, UK

    K. Hellmann

  2. Chester Beatty Research Institute, UK

    T. A. Connors

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© 1976 Plenum Press, New York

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Norpoth, K. (1976). Analogues and Metabolites of Cyclophosphamide. In: Hellmann, K., Connors, T.A. (eds) Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4349-3_16

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  • DOI: https://doi.org/10.1007/978-1-4613-4349-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4351-6

  • Online ISBN: 978-1-4613-4349-3

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