Abstract
In 1959, 1 -methyl-1 -nitroso-3-nitroguanidine (MNNG) was found to increase the life span of mice bearing leukaemia L1210 ( 1). While MNNG did not have sufficient activity to warrant extensive clinical testing, the demonstration of antitumour effect gave impetus for further evaluation of the N-nitroso class of compounds as potential antineoplastic agents. In 1961 1-methyl-1-nitrosourea (MNU) was reported to be not only more effective against intraperitoneally implanted L1210 than MNNG, but also was capable of penetrating the blood-brain barrier; MNU produced limited but reproducible antitumour activity in mice with intracerebral leukaemic cells ( 1). Since that time over 300 aIkyInitrosourea compounds have been screened for antitumour activity, the majority of the synthetic work having been undertaken by Montgomery, Johnston and co-workers at the Southern Research Institute (3).
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References
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© 1976 Plenum Press, New York
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Schein, P.S., Anderson, T., McMenamin, M.G., Bull, J. (1976). Streoptozotocin, Chlorozotocin and Related Nitrosourea Antitumour Agents. In: Hellmann, K., Connors, T.A. (eds) Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4349-3_15
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DOI: https://doi.org/10.1007/978-1-4613-4349-3_15
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