Chemotherapy pp 159-166 | Cite as

Streoptozotocin, Chlorozotocin and Related Nitrosourea Antitumour Agents

  • Phillip S. Schein
  • Tom Anderson
  • Mary G. McMenamin
  • Joan Bull


In 1959, 1 -methyl-1 -nitroso-3-nitroguanidine (MNNG) was found to increase the life span of mice bearing leukaemia L1210 ( 1). While MNNG did not have sufficient activity to warrant extensive clinical testing, the demonstration of antitumour effect gave impetus for further evaluation of the N-nitroso class of compounds as potential antineoplastic agents. In 1961 1-methyl-1-nitrosourea (MNU) was reported to be not only more effective against intraperitoneally implanted L1210 than MNNG, but also was capable of penetrating the blood-brain barrier; MNU produced limited but reproducible antitumour activity in mice with intracerebral leukaemic cells ( 1). Since that time over 300 aIkyInitrosourea compounds have been screened for antitumour activity, the majority of the synthetic work having been undertaken by Montgomery, Johnston and co-workers at the Southern Research Institute (3).


White Blood Cell Count Antitumour Activity Pyridine Nucleotide Bone Marrow Toxicity L1210 Leukaemia 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Phillip S. Schein
    • 2
    • 1
  • Tom Anderson
    • 2
    • 1
  • Mary G. McMenamin
    • 2
    • 1
  • Joan Bull
    • 2
    • 1
  1. 1.Medicine BranchNational Cancer InstituteBethesdaUSA
  2. 2.Division of Medical OncologyGeorgetown University School of MedicineWashington, D.C.USA

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