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Chemotherapy pp 119-127 | Cite as

Pharmacokinetics and Metabolism of Anticancer Drugs

  • Ti Li Loo

Abstract

The design of cancer chemotherapeutic agents would already have evolved from empiricism to rationalism if a unique structural feature exists that specifically confers anticancer activity on a chemical substance. In reality, the structures of anticancer drugs vary widely; this structural diversity dictates a similar diversity in the pharmacokinetics and metabolism of these drugs. Generally however, the pharmacological disposition and metabolism of a particular class of anticancer agents, the antimetabolites, closely mimic those of their natural counterparts, and a reasonable extrapolation can frequently be made.

Keywords

Anticancer Drug Drug Metabolism Antitumor Agent Nitrogen Mustard Anthracycline Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Ti Li Loo
    • 1
  1. 1.M.D. Anderson Hospital and Tumor InstituteThe University of Texas System Cancer CenterHoustonUSA

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