Neutropenia is a major factor predisposing the patient with leukemia to severe bacterial infections. In neutropenics, bacterial infections are most often due to gram negative bacilli (Ps. aeruginosa, E. coli, Klebsiella sp. ) and originate from sites such as lungs, pharynx, gastro-intestinal tract, perineal region and skin. Very often bacteremia is associated with these infections.
KeywordsAntimicrobial Therapy Severe Infection Empiric Therapy Neutropenic Patient Synergistic Combination
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- 4).Gaya, H.; Klastersky, J. ; Schimpff, S. ; Fière, D. ; Widmaier, S. ; Nagel, G. (1975). Prospective randomly controlled trial of three antibiotic combinations for empirical therapy of suspected spesis in neutropenic cancer patients. Europ. J. Cancer (in press).Google Scholar
- 5).Klastersky, J. ; Cappel, R. ; Daneau, D. (1972) Clinical significance of in vitro synergism between antibiotics in gram negative infections. Antimicrob. Ag. Chemother. 2 : 470–475.Google Scholar
- 8).Garrique, I. L. ; Sande, M. A. ; Utz, J. P. ; Mandell, G. L. ; Warner, J. F. ; Mc Gehee, R. F. ; Shadomy, S. (1973) Combined amphotericin B-flucytosine chemotherapy in human cryptococcosis (abstract). Proceedings of the 13th Interscience Conference on Antimicrobial Agents and Chemotherapy.Google Scholar