Skip to main content
SpringerLink
Log in

Guanylate Cyclase

  • Chapter
Eukaryotic Cell Function and Growth

Abstract

The natural occurrence of cyclic GMP was first reported in 1963 by Ashman et al. (2) who isolated the nucleotide from rat urine. In 1969 Goldberg et al. (32) and Ishikawa et al. (50) detected cyclic GMP in tissues from mammals and lower phyla. In the same year, three laboratories published reports of an enzyme, guanylate cyclase, that catalyzed the formation of cyclic GMP from GTP in cell-free systems (47, 50, 84, 99). Since then, a number of properties of guanylate cyclase have been extensively studied. This is a review of these properties and of some methodologic considerations based on our own work and on published literature.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

cyclic GMP:

guanosine 3’,5’-monophosphate

cyclic AMP:

adenosine 3’,5’-monophosphate

cyclic IMP:

inosine 3’,5’-monophosphate

cyclic dGMP:

2’-deoxyguanosine 3’,5’-monophosphate

References

  1. AMER, M.S., and MCKINNEY, G.R. (1973), The Pharmacologist 15, 157 (Abs)

    Google Scholar 

  2. ASHMAN, D.F., LIPTON, R., MELICOW, M.M. and PRICE, T.D. (1963), Biochem. Diphys. Res. Commun. 11, 330

    Article  CAS  Google Scholar 

  3. BARMASCH, M., PISAREV, M.A., and ALTSCHULER, N., (1973), Acta Endocrin. Panam. 4, 19

    Google Scholar 

  4. BENZINGER, R.E., FLETCHER, R.T., and CHADER, G.J. (1974), Science 183, 86

    Article  Google Scholar 

  5. BIRNBAUMER, L., POHL, S.L., and RODBELL, M. (1969), J. Biol. Chem. 244, 3468

    PubMed  CAS  Google Scholar 

  6. BITENSKY, M.W., MIKI, N., MARCUS, F.R., and KEIRNS, J.J. (1973), Life Sciences 13, 1451

    Article  CAS  Google Scholar 

  7. BÖHME, E. (1970), Eur. J. Biochem. 14, 422

    Article  PubMed  Google Scholar 

  8. BÖHME, E., and JAKOBS, K.H. (1973), International Research Communications System 3, 1

    Google Scholar 

  9. BÖHME, E., JUNG, R., and MECHLER, I. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol Eds) Vol. 38 199, Academic Press, N.Y.

    Google Scholar 

  10. BÖHME, E., and SCHULTZ, G. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol Eds) Volume 38, 27, Academic Press, N.Y.

    Google Scholar 

  11. BROOKER, G. (1972) in “Methods in Molecular Biology” (M. Chasin, ed.) Vol. 3, 82, Dekker, New York

    Google Scholar 

  12. CHRISMAN, T.D., GARBERS, D.L., and HARDMAN, J.G. (1974) Fed. Proc. 33, 1250 abs.

    Google Scholar 

  13. CHRISMAN, T.D., GARBERS, D.L., and HARDMAN, J.G. (1974) Abstract, Second International Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) ( G.I. Drummond, P. Greengard and G.A. Robison, eds.) Vol. 5, 823, Academic Press, New York

    Google Scholar 

  14. CHRISMAN, T.D., GARBERS, D.L., PARKS, M.A., and HARDMAN, J.G. (1975) J. Biol. Chem., 250, 374

    PubMed  CAS  Google Scholar 

  15. CHRISMAN, T.D. and HARDMAN, J.D., unpublished observations

    Google Scholar 

  16. CLARK, V.L., and BERNLOHR, R.W. (1972) Biochem. Biophys. Res. Commun. 46, 1570

    Article  PubMed  CAS  Google Scholar 

  17. CLELAND, W.W. (1970) in “The Enzymes” (ed. by P.D. Boyer) II, 1–65, Academic Press, New York

    Chapter  Google Scholar 

  18. CLELAND, W.W., DANENBERG, K.D., and SCHIMERLIK, M.I. (1972) Fed. Proc. 31, 850 abs.

    Google Scholar 

  19. DEHAËN, C. (1974) J. Biol. Chem. 249, 2756

    Google Scholar 

  20. DINNENDAHL, V. (1974) Naunyn-Schimedeberg’s Arch. Pharmacol. 284, 55

    Article  CAS  Google Scholar 

  21. DRUMMOND, G. and DUNCAN, L. (1970) J. Biol. Chem. 245, 976

    PubMed  CAS  Google Scholar 

  22. FERRENDELLI, J.A., KINSCHERF, D.A., and CHANG, M.M. (1973) Mol. Pharmacol. 9, 445

    PubMed  CAS  Google Scholar 

  23. FLAWIA, M.H. and TORRES, H.N, (1972) J. Biol. Chem. 247, 6873

    PubMed  CAS  Google Scholar 

  24. GARBERS, D.L., CHRISMAN, T.D. and HARDMAN, J.G. (1974) Abstracts, Second Int. Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975), ( G.I. Drummond, P. Greengard and G.A. Robison, eds.) Vol. 5, 823, Academic Press, New York.

    Google Scholar 

  25. GARBERS, D.L., CHRISMAN, T.D., SUDDATH, J.L., and HARDMAN, J.D. (1975) Arch. Biochem. Biophys, 166, 135

    Article  PubMed  CAS  Google Scholar 

  26. GARBERS, D.L., DYER, E.L., and HARDMAN, J.G. (1975) J. Biol. Chem. 250, 382

    PubMed  CAS  Google Scholar 

  27. GARBERS, D.L. and HARDMAN, J.G. 1975, J. Biol. Chem. 250, 2482

    PubMed  CAS  Google Scholar 

  28. GARBERS, D.L. and HARDMAN, J.G., unpublished observations

    Google Scholar 

  29. GARBERS, D.L., HARDMAN, J.G. and RUDOLPH, F.B. (1974) Biochemistry, 13, 4166

    Article  CAS  Google Scholar 

  30. GARBERS, D.L. and JOHNSON, R.A., manuscript in preparation

    Google Scholar 

  31. GARBERS, D.L., SUDDATH, J.L., and HARDMAN, J.G. (1975) Biochim. Bipphys. Acta, 377, 174

    CAS  Google Scholar 

  32. GOLDBERG, N.D., DIETZ, S.B., and O’TOOLE, A.G. (1969) J. Biol. Chem. 244, 4458

    PubMed  CAS  Google Scholar 

  33. GOLDBERG, N.D. and HADDOX, M.K. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol. Eds.) Vol. 38, 73, Academic Press, N.Y.

    Google Scholar 

  34. GOLDBERG, N.D., HADDOX, M.K., HARTLE, D.K., and HADDEN, J.W. (1973) “Pharmacology and the Future of Man”. Proc. 5th International Congress of Pharmacology, San Francisco, Vol. 5, 146, Karger, Basel, Switzerland

    Google Scholar 

  35. GOLDBERG, N.D., O’DEA, R.F., and HADDOX, M.K. (1973) “Advances in Cyclic Nucleotide Research” 3, 155

    PubMed  CAS  Google Scholar 

  36. GOOD, N.E., WINGET, G.D., WINTER, W., CONNOLLY, T.N., IZAWA, S., and SINGH, R.M.M. (1966) Biochemistry 5, 467

    Article  PubMed  CAS  Google Scholar 

  37. GORIDIS, C. and MORGAN, I.G. (1973) FEBS LETTERS 34, 71

    Article  PubMed  CAS  Google Scholar 

  38. GORIDIS, C., VIRMAUX, N., URBAN, P.F., and MANDEL, P. (1973) FEBS LETTERS 30, 163

    Article  PubMed  CAS  Google Scholar 

  39. GRAY, J.P. (1971) “Cyclic AMP and Cyclic GMP in Gametes” Ph. D. Dessertation, Vanderbilt University Medical School Library, Nashwille, Tennessee

    Google Scholar 

  40. GRAY, J.P. and DRUMMOND, G.I. (1973) Proc. Can. Fed. Biol. Soc. 16, 79 (abs.)

    Google Scholar 

  41. GRAY, J.P. and DRUMMOND, G.I. (1974) Fed. Proc. 33, 1250 (abs.)

    Google Scholar 

  42. GRAY, J.P., HARDMAN, J.G., BIBRING, T., and SUTHERLAND, E.W. (1970) Fed. Proc. 29, 608 (abs.)

    Google Scholar 

  43. GRAY, J.P., HARDMAN, J.G., HAMMER, J.L., HOOS, R.T. and SUTHERLAND, E.W. (1971) Fed. Proc. 30, 1267 (abs.)

    Google Scholar 

  44. GRAY, J.P., LUK, D., and DRUMMOND, G.I. (1974) Abstracts, Second Int. Conference on Cyclic AMP, Vancouver, “Advances in Cyclic Nucleotide Research” (1975) (G.I. Drummond, P. Greengard and G.A. Robison, eds.) Vol. 5, 823, Academic Press, New York

    Google Scholar 

  45. HARDMAN, J.G., BEAVO, J.A., GRAY, J.P., CHRISMAN, T.D., PATTERSON, W.D., and SUTHERLAND, E.W. (1971) Ann.N.Y. Acad. Sci. 185, 27

    Article  PubMed  CAS  Google Scholar 

  46. HARDMAN, J.G., CHRISMAN, T.D., GRAY, J.P., SUDDATH, J.L., and SUTHERLAND, E.W. (1973) “Pharmacology and the Future of Man”. Proc. 5th International Congress of Pharmacology, San Francisco, Vol. 5, 134, Karger, Basel, Switzerland

    Google Scholar 

  47. HARDMAN, J.G. and SUTHERLAND, E.W. (1969) J. Biol. Chem. 244, 6363

    PubMed  CAS  Google Scholar 

  48. HAYAISHI, O., GREENGARD, P., and COLOWICK, S.P. (1971) J. Biol. Chem. 246, 5840

    PubMed  CAS  Google Scholar 

  49. HIRATA, M. and HAYAISHI, O. (1966) Biochem. Biophys. Res. Comm. 24, 360

    Article  PubMed  CAS  Google Scholar 

  50. ISHIKAWA, E., ISHIKAWA, S., DAVIS, J.W., and SUTHERLAND, E.W. (1969) J. Biol. Chem. 244, 6371

    PubMed  CAS  Google Scholar 

  51. JOHNSON, R.A., and PILKIS, S.J. (1974) Abstracts, Second International Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) ( G.I. Drummond, P. Greengard, and G.A. Robison, eds.) Vol. 5, 808 Academic Press, New York

    Google Scholar 

  52. JOHNSON, R.A., and SUTHERLAND, E.W. (1973), J. Biol. Chem. 5114

    Google Scholar 

  53. JUNE, R., MECHLER, I., MOCIKAT, S., and BÖHME, E. (1972) Naunyn-Schmiedeberg’s Archives of Pharmacology, 294 (Supp.) R59

    Google Scholar 

  54. KIM, G., and SILVERSTEIN, E. (1974) Fed. Proc. 33, 1250 (abs.)

    Google Scholar 

  55. KIMURA, H., and MURAD, F. (1974) J. Biol. Chem. 249, 329

    PubMed  CAS  Google Scholar 

  56. KIMURA, H., and MURAD, F. (1974) Abstracts, Second.International Conference on Cyclic AMP, Vancouver, in “Advance Cyclic Nucleotide Research” (1975) (G.I. Drummond, P. Greengard and G.A. Robison, ed.) Vol. 5, 822, Academic Press, New York

    Google Scholar 

  57. KIMURA, H. and MURAD, F. (1974) Fed. Proc. 33 (Part I), 479

    Google Scholar 

  58. KIMURA, H. and MURAD, F. (1974) J. Biol. Chem. 249, 6910

    PubMed  CAS  Google Scholar 

  59. KOSHLAND, D.E., Jr. (1970) in “The Enzymes” (Boyer, P.D. ed) 3rd Ed. Vol. 1, 341

    Chapter  Google Scholar 

  60. KRISHNA, G., KRISHNAN, N., FLETCHER, T., and CHADER, G. (1974) Abstracts, Second International Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) (G.I. Drummond, P. Greengard and G.A. Robison, eds.) Vol. 5, 823

    Google Scholar 

  61. KRISHNAN, N., and KRISHNA, G. (1974) Fed. Proc. 33, 1250 (abs.)

    Google Scholar 

  62. KRISHNAN, N., and KRISHNA, G. (1974) Abstracts, Second International Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) ( G.I. Drummond, P. Greengard, G.A. Robinson, eds.) Volume 5, 820, Academic Press, New York

    Google Scholar 

  63. KUO, J.F., LEE, T.P., REYES, P.L., WALTON, K.G., DONNELLY, T.G., Jr., and GREENGARD, P. (1972) J. Biol. Chem. 247, 16

    PubMed  CAS  Google Scholar 

  64. LIMBIRD, L.E., and LEFKOWITZ, R.J. (1974) Abstracts, Second International Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) ( G.I. Drummond, P. Greengard and G.A. Robison, eds.) Volume 5, 823 Academic Press, New York

    Google Scholar 

  65. MARKS, F., (1973) Biochim. Biophys. Acta 309, 349

    PubMed  CAS  Google Scholar 

  66. McCLURE, W.R., LARDY, H.A., and KNEIFEL, H.P. (1971) J. Biol. Chem. 246, 3569

    PubMed  CAS  Google Scholar 

  67. McMILLAN, B.H., NEY, R.L., and SCHORR, I. (1971) Endocrinology 89, 281

    Article  PubMed  CAS  Google Scholar 

  68. MONTAGUE, W. and HOWELL, S.L. (1974) Abstracts, Second Int. Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) ( G.I. Drummond, P. Greengard and G.A. Robison, eds.) Vol. 5, 822, Academic Press, New York

    Google Scholar 

  69. MORRISON, J.F., and EBNER, K.E. (1971) J. Biol. Chem. 246, 3977

    PubMed  CAS  Google Scholar 

  70. MORRISON, J.F. and EBNER, K.E. (1971) J. Biol. Chem. 246, 3985

    PubMed  CAS  Google Scholar 

  71. MURAD, F., MANGANIELLO, V., and VAUGHAN, M. (1971) Proc. Nat. Acad. Sci. (USA) 68, 736

    Article  CAS  Google Scholar 

  72. NAKAZAWA, K. and SANO, M. (1974) J. Biol. Chem. 249, 4207

    PubMed  CAS  Google Scholar 

  73. O’DEA, R.F., BODLEY, J.W., LIN, L., HADDOX, M.K., and GOLDBERG, N.D. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol. Eds.) Vol. 38, 85, Academic Press, N.Y.

    Google Scholar 

  74. O’SULLIVAN, W.J. and PERRIN, D.D. (1964) Biochemistry 3, 18

    Article  PubMed  Google Scholar 

  75. ØYE, I. and SUTHERLAND, E.W. (1966) Biochim. Diophys. Acta 127, 347

    Google Scholar 

  76. PANNBACKER, R.G. (1973) Science 182, 1138

    Article  PubMed  CAS  Google Scholar 

  77. PERKINS, J.P. (1973) “Adv. Cyclic Nucleotide Research” (P. Greengard and G.A. Robison, eds.) 3, 1

    Google Scholar 

  78. PETRACK, B., MA, D., and SHEPPY, F. (1974) J. Biol. Chem. 249, 3661

    PubMed  CAS  Google Scholar 

  79. RALL, T.W. and SUTHERLAND, E.W. (1962) J. Biol. Chem. 237, 1228

    PubMed  CAS  Google Scholar 

  80. RODBELL, M., BIRNBAUMER, L., POHL, S.L., and KRANS, H.M. (1971) J. Biol. Chem. 246, 1877

    PubMed  CAS  Google Scholar 

  81. RUSSELL, T.R., TERASAKI, W., and APPLEMAN, M.M. (1973) J. Biol. Chem. 248, 1334

    PubMed  CAS  Google Scholar 

  82. SCHULTZ, G. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol. Eds.) Vol. 38, 115, Academic Press, New York

    Google Scholar 

  83. SCHULTZ, G., BÖHME, E., and HARDMAN, J.G. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol. Eds.) Vol. 38, 9, Academic Press, New York

    Google Scholar 

  84. SCHULTZ, G., BÖHME, E., and MUNSKE, K. (1969) Life Sciences 8, 1323

    Article  PubMed  CAS  Google Scholar 

  85. SCHULTZ, G., HARDMAN, J.G., SCHULTZ, K., BAIRD, C.E., and SUTHERLAND, E.W. (1973) Proc. Nat. Acad. Sci. (USA) 70, 3889

    Article  CAS  Google Scholar 

  86. SCHULTZ, G., HARDMAN, J.G., SCHULTZ, K., DAVIS, J.W., and SUTHERLAND, E.W. (1973) Proc. Nat. Acad. Sci. (USA) 70, 1721

    Article  CAS  Google Scholar 

  87. SCHULTZ, G., JAKOBS, K.H., BÖHME, E., and SCHULTZ, K. (1972) Eur. J. Biochem. 24, 520

    Article  PubMed  CAS  Google Scholar 

  88. SCHULTZ, G., Schultz, K., and HARDMAN, J.G. (1974) Metabolism, in press

    Google Scholar 

  89. SEIFERT, W., and RUDLAND, P.S. (1974) Abstracts, Second Int. Conference on Cyclic AMP, Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) (G.I. Drummond, P. Greengard and G.A. Robison, eds.) Vol. 5, 822, Academic Press New York

    Google Scholar 

  90. SHIMA, S. (1974) Abstracts, Second Int. Conference on Cyclic AMP Vancouver, in “Advances in Cyclic Nucleotide Research” (1975) ( G.I. Drummond, P. Greengard and G.A. Robison, ed.) Vol. 5, 823, Academic Press, New York

    Google Scholar 

  91. SILLEN, L.G. and MARTELL, A.E. (1971) “Stability Constants of Metal Ion Complexes,” Supplement 1, The Chemical Society, Burlington House, London

    Google Scholar 

  92. STEINER, A.L., PAGLIARA, A.S., CHASE, L.R., and KIPNIS, D.M. (1972) J. Biol. Chem. 247, 1114

    PubMed  CAS  Google Scholar 

  93. STONER, J., MANGANIELLO, V.C., and VAUGHAN, M. ( 1974 Mol. Pharmacol. 10, 155

    PubMed  CAS  Google Scholar 

  94. SUTHERLAND, E.W., RALL, T.W., and MENON, T. (1962) J. Biol. Chem. 237, 1220

    PubMed  CAS  Google Scholar 

  95. TAKAI, K., KURASHINA, Y., SUZUKI, C., OKAMOTO, H., UEKI, A., and HAYAISHI, O. (1971) J. Biol. Chem. 246, 5843

    PubMed  CAS  Google Scholar 

  96. THOMPSON, W.J., JOHNSON, D.G., LAVIS, V.R., and WILLIAMS, R.H. (1974) Endocrinology 94, 276

    Article  PubMed  CAS  Google Scholar 

  97. THOMPSON, W.J., WILLIAMS, R.H., and LITTLE, S.A. (1973) Arch. Biochem. Biophys. 159, 206

    Article  PubMed  CAS  Google Scholar 

  98. THOMPSON, W.J., WILLIAMS, R.H., and LITTLE, S.A. (1973) Biochim. Biophys. Acta 302, 329

    PubMed  CAS  Google Scholar 

  99. WHITE, A.A. and AURBACH, G.D. (1969) Biochim. Biophys. Acta 191, 686

    PubMed  CAS  Google Scholar 

  100. WHITE, A.A., NORTHUP, S.J., and ZENSER, T.V. (1972) in “Methods in Cyclic Nucleotide Research” (Chasin, M., ed.) 125, Marcel Dekker, New York

    Google Scholar 

  101. WHITE, A.A., and ZENSER, T.V. (1971) Anal. Biochem. 41, 372

    Article  PubMed  CAS  Google Scholar 

  102. WHITE, A.A., and ZENZER, T.V. (1974) in “Methods in Enzymology” (J.G. Hardman and B.W. O’Malley, Vol. Eds.) Vol. 38, 192, Academic Press, New York

    Google Scholar 

  103. WHITE, L.E., IGNARRO, L.J., and GEORGE, W.J. (1973). The Pharmacologist 15, 157 (abs.)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    David L. Garbers, Ted D. Chrisman & Joel G. Hardman

Authors
  1. David L. Garbers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ted D. Chrisman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joel G. Hardman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Garbers, D.L., Chrisman, T.D., Hardman, J.G. (1976). Guanylate Cyclase. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation