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Diseases Involving Cyclic AMP

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Eukaryotic Cell Function and Growth

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Abstract

In view of the wide variety of physiological functions in which cAMP plays a crucial role, it is not surprising that the metabolism of the cyclic nucleotide is involved in several diseases. In this lecture, the studies of the cAMP system that have been performed in a certain number of endocrinopathies and other disorders will be reviewed. Most of the data presented will concern human pathology but occasional reference will be made to animal experiments that have provided fundamental understanding of the disease process. The eventual role of cAMP in cancer has been covered in detail in other lectures of this series. Since much of the knowledge concerning the pathology of cAMP has been gathered from the analysis of plasma and especially urine, a survey of the data concerning the concentration of the cyclic nucleotide in these body fluids will be given first. The diseases involving the metabolism of cAMP will be classified into those in which a decreased formation of cAMP has been described, and those in which an increased production of the cyclic nucleotide has been reported.

“Bevoegdverklaard Navorser” of the “National Fonds voor Wetenschappelijk onderzoek”

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Authors and Affiliations

  1. Laboratoire de Chimie Physiologique, International Institute of Cellular and Molecular Pathology, Université de Louvain, Avenue Hippocrate, 75, B-1200, Brussels, Belgium

    Georges Van den Berghe

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  1. Georges Van den Berghe
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Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

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© 1976 Plenum Press, New York

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Van den Berghe, G. (1976). Diseases Involving Cyclic AMP. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_42

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  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_42

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4613-4322-6

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