Skip to main content
SpringerLink
Log in
Book cover

Eukaryotic Cell Function and Growth pp 759–771Cite as

Cyclic AMP and Cancer

  • Chapter

  • 75 Accesses

Abstract

Fibroblasts grown in monolayer on Petri dishes display various characteristics some of which help one to differentiate normal from malignant cells. For example, malignant fibroblasts, also called “transformed” cells, usually grow faster than their normal counterpart, they do not show density-dependent inhibition of growth, they move more rapidly, adhere less to the substratum, etc. Considering that cAMP mediates the regulation of numerous functions in all kinds of cells, mostly those functions which are characteristic of the differentiated state of a cell line, it was reasonable to hypothesize that cAMP was involved in the expression of those properties in cultured fibroblasts which distinguish normal from malignant cells.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

cAMP:

3′, 5′ cyclic adenosine monosphate

Bt2cAMP:

N6, O2-dibutyryl cyclic AMP

CEF:

chick embryo fibroblasts

RSV:

Rons sarcoma virus

RSV-Ts:

temperature sensitive mutant of Rons sarcoma virus

References

  1. Johnson, G.S., Friedman, R.M., and Pastan, I. (1971) Ann. N.Y. Acad. Sci., 85, 413

    Article  Google Scholar 

  2. Johnson, G.S., Friedman, R.M., and Pastan, I., (1971), Proceed. Natl. Acad. Sci. (USA) 68, 425

    Article  CAS  Google Scholar 

  3. Heidrick, M.L., and Ryan, W.L. (1971), Cancer Res., 31, 1313

    PubMed  CAS  Google Scholar 

  4. Johnson, G.S. and Pastan, I. (1972), J. Natl. Cancer Inst., 48, 1377

    PubMed  CAS  Google Scholar 

  5. Otten, J., Johnson, G.S., and Pastan, I. (1972), J. Biol. Chem., 247, 7082

    PubMed  CAS  Google Scholar 

  6. Johnson, G.S., and Pastan, I (1972), Nature, New Biol., 235, 54

    Article  CAS  Google Scholar 

  7. Johnson, G.S., and Pastan, I (1972), Nature, New Biol., 236, 247

    Article  CAS  Google Scholar 

  8. Hsie, A.W., Jones, C. and Puck, T.T. (1971) Proc. Natl. Acad. Sci. (USA), 68, 1648

    Article  CAS  Google Scholar 

  9. Sheppard, J.R. (1972), Nature, New Biol., 236, 14

    CAS  Google Scholar 

  10. Otten, J., Johnson, G.S., and Pastan, I (1971) Biochem. Biophys. Res. Comm., 44, 1192

    Article  PubMed  CAS  Google Scholar 

  11. Carchman, R.A., Johnson, G.S., Pastan, I., and Scolnick, E.M., (1974), Cell. 1, 59

    Article  CAS  Google Scholar 

  12. Paul, D. (1970), Nature, New Biol., 240, 179

    Google Scholar 

  13. Kram, R. et al. (in this volume)

    Google Scholar 

  14. Otten, J., Bader, J., Johnson, G.S., and Pastan, I. (1972) J. Biol. Chem., 247, 1632

    PubMed  CAS  Google Scholar 

  15. Anderson, W.B., Lovelace, E., and Pastan, I. (1973), Biochem. Biophys. Res. Comm., 52, 1293

    Article  PubMed  CAS  Google Scholar 

  16. Anderson, W.B., Johnson, G.S., and Pastan, I. (1973) Proceed. Natl. Acad. Sci. (USA), 70, 1055

    Article  CAS  Google Scholar 

  17. Bürk, R.R. (1968), Nature, 219, 1272

    Article  Google Scholar 

  18. Makman, M.H. (1971) Proceed. Natl. Acad. Sci. (USA), 68, 2127

    Article  CAS  Google Scholar 

  19. Perry, C.V., Johnson, G.S., and Pastan, I. (1971) J. Biol. Chem., 246, 5785

    Google Scholar 

  20. Bader, J.P., and Brown, N.R. (1971), Nature, New Biol., 234, 11

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut de Recherche Interdisciplinaire, School of Medicine, University of Brussels, Belgium

    J. Otten

Authors
  1. J. Otten
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Otten, J. (1976). Cyclic AMP and Cancer. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_39

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation