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Role of Cyclic Nucleotides in the Anterior Pituitary Gland

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Eukaryotic Cell Function and Growth

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Abstract

It is now well established that a number of hormones synthesised in the hypothalamic area and carried to their adenohypophyseal site of action by a portal system, act to modulate the release of anterior pituitary hormones. Some of these hypothalamic regulating factors have now been characterised. The first to be demonstrated (1) was corticotrophin releasing factor (CRF); however, its structure is still not known. Thyrotrophin releasing hormone (TRH) was the first hypothalamic factor to be fully characterised, largely through the efforts of two groups led by Guillemin and Schally respectively (2,3) and shown to be a tripeptide (pyroglutamyl-histidyl-proline amide). The synthesis of TRH was closely followed by the identification and synthesis of gonadotrophin releasing hormone (GnRH), a decapeptide which stimulates the release of both LH and FSH.

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Abbreviations

TSH:

thyroid stimulating hormone (thyrotrophin)

LH:

luteinising hormone

FSH:

follicle stimulating hormone

ACTH:

Adrenocorticotrophic hormone

GH:

growth hormone

TRH:

thyrotrophin releasing hormone

GnRH (also LHRH):

Gonadotropin releasing hormone

CRF:

corticotrophin releasing factor

GHRH:

growth hormone releasing hormone

GHRIH (somatostatin):

growth hormone release inhibiting hormone

PRF:

prolactin releasing factor

PIF:

Prolactin inhibiting factor

TS:

Triiodothyronine

T4:

Thyroxine

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, The Middlesex Hospital Medical School, Thorn Institute of Clinical Science, Mortimer Street, London, W1N 8AA, UK

    B. L. Brown

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  1. B. L. Brown
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Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

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© 1976 Plenum Press, New York

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Brown, B.L. (1976). Role of Cyclic Nucleotides in the Anterior Pituitary Gland. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_32

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  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

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