Skip to main content
SpringerLink
Log in

Insulin Secretion — The Role and Mode of Action of Cyclic AMP

  • Chapter
Book cover Eukaryotic Cell Function and Growth

Abstract

There is much evidence to suggest that intracellular levels of cyclic AMP in endocrine cells may play an important role in determining rates of hormone release, and that many secretagogues influence cyclic AMP levels, and hence rates of secretion, by interaction with receptors which are related to adenylate cyclase, or by inhibition of phosphodiesterase. A mechanism of this type seems to operate during activation of secretion by physiological agents in, for instance, the anterior pituitary (1) and thyroid (2). A widely accepted model for the regulation of hormone secretion is shown in Fig. 1, and i t is the purpose of this paper to determine how far this model is applicable to the regulation of insulin secretion by the B cells of mammalian islets of Langerhans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Steiner, A.L., Peake, G.T., Utiger, R.D., Karl, I.C. and Kipnis, D.M. (1970): Endocrinology, 86: 1354–1363.

    Article  PubMed  CAS  Google Scholar 

  2. Dumont, J.E., Willems, C., Van Sande, J. and Neve, P. (1971): Annals of New York Academy of Science, 185: 291–316.

    Article  CAS  Google Scholar 

  3. Moskalewski, S. (1965): General and Comparative Endocrinology, 5: 342–353.

    Article  Google Scholar 

  4. Kostianovsky, M. and Lacy, P.E. (1966): Federation Proceedings, 25: 377.

    Google Scholar 

  5. Curry, D.L., Bennett, L.L. and Grodsky, G.M. (1968): Endocrinology, 83: 572–584.

    Article  PubMed  CAS  Google Scholar 

  6. Howell, S.L. and Taylor, K.W. (1966): Biochimica et Biophysica Acta, 130: 519–521.

    PubMed  CAS  Google Scholar 

  7. Howell, S.L. and Taylor, K.W. (1967): Biochemical Journal, 102: 922–927.

    PubMed  CAS  Google Scholar 

  8. Lacy, P.E. (1961): American Journal of Medicine, 31: 851–859

    Article  PubMed  CAS  Google Scholar 

  9. Dean, P.M. (1973): Diabetologia, 9: 115–119.

    Article  PubMed  CAS  Google Scholar 

  10. Lacy, P.E., Howell, S.L., Young, D.A. and Fink, C.J. (1968): Nature, 219: 1177–1179.

    Article  PubMed  CAS  Google Scholar 

  11. Malaisse, W.J., Malaisse-Lagae, F., Walker, M.O. and Lacy, P.E. (1971): Diabetes, 20: 257–265.

    PubMed  CAS  Google Scholar 

  12. Lacy, P.E. and Malaisse, W.J. (1973): Recent Progress in Hormone Research, 29: 199–228.

    PubMed  CAS  Google Scholar 

  13. Coore, H.G. and Randle, P.J. (1964): Biochemical Journal, 93: 66–78.

    PubMed  CAS  Google Scholar 

  14. Grodsky, G.M. and Bennett, L.L. (1966): Diabetes, 15: 910–913.

    PubMed  CAS  Google Scholar 

  15. Steiner, D.F., Kemmler, W., Clark, J.L., Oyer, P.E. and Rubenstein, A.H. (1972): Handbook of Physiology, Section 7, Vol.1, edited by D.F.Steiner and N.Freinkel. American physiological Society, pp 175–198.

    Google Scholar 

  16. Howell, S.L. and Whitfield, M. (1972): Journal of Histochemistry and Cytochemistry, 20: 873–879.

    Article  PubMed  CAS  Google Scholar 

  17. Atkins, T. and Matty, A.J. (1971): Journal of Endocrinology, 5l: 67–780

    Article  Google Scholar 

  18. Davis, B. and Lazarus, N.R. (1972): Biochemical Journal, 129: 373–379.

    PubMed  CAS  Google Scholar 

  19. Ku., W., Hodgins, D.S. and Kuo, J.F. (1973): Journal of Biological Chemistry, 248: 2705–2711.

    Google Scholar 

  20. Howell, S.L. and Montague, W. (1973): Biochimica et Biophysica Acta, 320: 44–52.

    PubMed  CAS  Google Scholar 

  21. Grill, V. and Cerasi, E. (1974): Journal of Biological Chemistry, 249: 4196–4201.

    PubMed  CAS  Google Scholar 

  22. Miller, E.A., Wright, P.H. and Allen, D.O. (1972): Endocrinology, 91: 1117–1119.

    Article  PubMed  CAS  Google Scholar 

  23. Rosen, O.M., Hirsch, A.H. and Goren, E.N. (1971): Archives of Biochemistry and Biophysics, 146: 660–663.

    Article  PubMed  CAS  Google Scholar 

  24. Goldfine, I.D., Roth, J. and Birnbaumer, L. (1972): Journal of Biological Chemistry, 247: 1211–1218.

    PubMed  CAS  Google Scholar 

  25. Johnson, D.G., Thompson, W.J. and Williams, R.H. ( 1974: Biochemistry, 13: 1920–1924.

    Article  PubMed  CAS  Google Scholar 

  26. Goldfine, I.D., Perlman, R. and Roth, J. (1971): Nature, 234: 295–297.

    Article  PubMed  CAS  Google Scholar 

  27. Schubart, U., Udem, L., Baum, S. and Rosen, O.M. (1973): Diabetes, 22, Suppl. 1: 306.

    Google Scholar 

  28. Sams, D.J. and Montague, W. (1972): Biochemical Journal, 129: 945–952.

    PubMed  CAS  Google Scholar 

  29. Ashcroft, S.J.H., Randle, P.J. and Taljedal, I.B. (1972): FEBS letters, 20: 263–266.

    Article  PubMed  CAS  Google Scholar 

  30. Bowen, V. and Lazarus, N.R. (1973): Diabetes, 22: 738–743.

    PubMed  CAS  Google Scholar 

  31. Montague, W. and Howell, S.L. (1973): Biochemical Journal, 134: 321–327.

    PubMed  CAS  Google Scholar 

  32. Dods, R.F. and Burdowski, A. (1973): Biochemical and Biophysical Research Communications, 51: 421–427.

    Article  PubMed  CAS  Google Scholar 

  33. Müller, W.A. and Sharp, G.W.G. (1974): Diabetologia, 10: 380.

    Google Scholar 

  34. Montague, W. and Howell, S.L. (1972): Biochemical Journal, 129: 551–560.

    PubMed  CAS  Google Scholar 

  35. Davis,B. and Lazarus, N.R. (1973): Excerpta Medica ICS, 280, p7.

    Google Scholar 

  36. Erlichman, J., Hirsch, A.H. and. Rosen, O.M. (1971): Proceedings of the National Academy of Sciences, 68: 731–735.

    Article  CAS  Google Scholar 

  37. Gill, G.N. and Garren, L.D. (1971): Proceedings of the National Academy of Sciences, 68: 786–790.

    Article  CAS  Google Scholar 

  38. Reimann, E.M., Walsh, D.A. and Krebs, E.G. (1971): Journal of Biological Chemistry, 246: 1986–1995.

    PubMed  CAS  Google Scholar 

  39. Cerasi, E., Effendic, S. and Luft, R. (1969): Lancet, 2: 301–302.

    Article  PubMed  CAS  Google Scholar 

  40. Levey, C.S., Schmidt, W.M.T. and Mintz, D.H. (1972): Metabolism, 21: 93–98.

    Article  PubMed  CAS  Google Scholar 

  41. Steiner, D.F. (1972): Diabetes, 21, Suppl. 2: 571.

    Google Scholar 

  42. Kipnis, D.M. (1970): Acta Diabetologica Latina 7, Suppl. 1: 314–337.

    Google Scholar 

  43. Montague, W. and Cook, J.R. (1971): Biochemical Journal, 122: 115–120.

    PubMed  CAS  Google Scholar 

  44. Cooper, R.H., Ashcroft, S.J.H. and Randle, P.J. (1973): Biochemical Journal, 143: 599–605.

    Google Scholar 

  45. Hellman, B., Idahl, L.A., Lernmark, A. and Täljedal, I.B. (1974): Proceedings of the National Academy of Sciences, 71 No. 9, 3405–3409.

    Article  CAS  Google Scholar 

  46. Charles, M.A., Fanska, R., Schmid, F.G., Forsham, P.H. and Grodsky, G.M. (1973): Science, 179: 569–571.

    Article  PubMed  CAS  Google Scholar 

  47. Zawalich, W., Ferrendelli, J. and Matschinsky, F.M. (1973): Diabetes, 22: 331.

    Google Scholar 

  48. Milner, R.D.G. (1970): Biochimica et Biophysica Acta, 192: 154–156.

    Google Scholar 

  49. Effendic, S., Cerasi, E. and Luft, R. (1972): Journal of Clinical Endocrinology, 34: 67–72.

    Article  Google Scholar 

  50. Malaisse, W.J., Malaisse-Lagae, F. and King, S. (1968): Diabetologia, 4: 370–375.

    Article  PubMed  CAS  Google Scholar 

  51. Charles, M.A., Lawecki, J. and Grodsky, G.M. (1973): Diabetes, 22: Suppl. 1: 297.

    Google Scholar 

  52. Sams, D.J. and Montague, W. (1974): Biochemical Society Transactions, 2: 411–412.

    CAS  Google Scholar 

  53. Johnson, D.G., Fujimot., E.Y. and Williams, R.H. (1973): Diabetes, 22: 658–663.

    PubMed  CAS  Google Scholar 

  54. Bressler, R., Vargas-Cordon, M. and Lebovitz, H.E. (1968): Diabetes, 17: 617–624.

    PubMed  CAS  Google Scholar 

  55. Lefèbvre, P.J. and Luyckx, A.S. (1972): Diabetes, Suppl. 1, 21: 369.

    Google Scholar 

  56. Thompson, W.J., Johnson, D.G. and Williains, R.H. (1973): Diabetes, 23, Suppl. 1: 297.

    Google Scholar 

  57. Turtle, J.R. and Kipnis, D.M. (1967): Biochemical and Biophysical Research Communications, 28: 797–802.

    Article  PubMed  CAS  Google Scholar 

  58. Selawry, H., Marcks, C., Fink, G., Lavine, R., Cresto, J. and Recant., L. (1973): Diabetes, 22, Suppl. 1: 295.

    Google Scholar 

  59. Malaisse, W.J., (1973): Diabetologia, 9: 167–173.

    Article  PubMed  CAS  Google Scholar 

  60. Green, I.C. and Taylor, K.W. (1972): Journal of Endocrinology, 54: 317–325.

    Article  PubMed  CAS  Google Scholar 

  61. Green, I.C., Howell, S.L., Montague, W. and Taylor, K.W. (1973): Biochemical Journal, 134. 481–487.

    PubMed  CAS  Google Scholar 

  62. Green, I.C. and Taylor, K.W. (1974): Journal of Endocrinology, 62: 137–143.

    Article  PubMed  CAS  Google Scholar 

  63. Costrini, N.V. and Kalkhoff, R.K. (1971): Journal of Clinical Investigation, 50:992–999.

    Article  PubMed  CAS  Google Scholar 

  64. Malaisse, W.JQ, Malaisse-Lagae, F. and Wright, P.H. (1967): American Journal of Physiology, 213: 843–848.

    PubMed  CAS  Google Scholar 

  65. Grey, N.J., Goldring, S. and Kipnis, D.M. (1970): Journal of Clinical Investigation, 49: 881–889.

    Article  PubMed  CAS  Google Scholar 

  66. Howell, S.L., Green, I.C. and Montague, W. (1973): Biochemical Journal, 136: 343–349.

    PubMed  CAS  Google Scholar 

  67. Miyamot., E., Ku., J.F. and Greengard, P. (1969): Journal of Biological Chemistry, 244: 6395–6402.

    Google Scholar 

  68. Walsh, D.A. and Ashby, C.D. (1973): Recent Progress in Hormone Research, 29: 329–359.

    PubMed  CAS  Google Scholar 

  69. Malaisse, W.J., Malaisse-Lagae, F. and Mayhew, D. (1967): Journal of Clinical Investigation, 46: 1724–1734.

    Article  PubMed  CAS  Google Scholar 

  70. Randle, P.J., Ashcroft, S.J.H. and Gill, J.R. (1968): Carbohydrate Metabolism and its Disorders, Vol.1, edited by F.Dickens, P.J., Randle and W.J.Whelan. Academic Press, London, pp. 427–447.

    Google Scholar 

  71. Samols, E., Marri, G. and Marks, V. (1966): Diabetes, 15: 855–866.

    PubMed  CAS  Google Scholar 

  72. Idahl, D.A. and Hellman, B. (1971): Diabetologia, 7: 139–142

    Article  PubMed  CAS  Google Scholar 

  73. Ashcroft, S.J.H., Hedeskov, C.J. and Randle, P.J. (1970): Biochemical Journal, 118: 143–154.

    PubMed  CAS  Google Scholar 

  74. Hellerström, C. and Gunnarsson, R (1970): Acta Diabetologica Latina, 7, Suppl. 1: 127–151.

    Google Scholar 

  75. Rasmussen, H. (1970): Science, 170: 404–412.

    Article  PubMed  CAS  Google Scholar 

  76. Reddington, M. and Lagnad., J.R. (1973): FEBS Letters, 30: 188–194.

    Article  PubMed  CAS  Google Scholar 

  77. Leterrier, J.P., Rappaport, L. and Nunez, J. (1974): Molecular and Cellular Endocrinology 1: 65–75.

    Article  CAS  Google Scholar 

  78. Rasmussen, H. and Tenenhouse, A. (1968): Proceedings of the National Academy of Sciences, 59: 1364–1370.

    Article  CAS  Google Scholar 

  79. Howell, S.L. and Montague, W. (1975): FEBS Letters 52, 48–52.

    Article  PubMed  CAS  Google Scholar 

  80. Borle, A. (1974) J.Membrane Biol. 16, 221–236.

    Article  CAS  Google Scholar 

  81. Davis, B. and Lazarus, N.R. (1974): Biochemical Society Transactions, 2, No. 3, 409–411.

    Google Scholar 

  82. Burr, I.M., Balant, L., Stauffacher, W. and Renold, A.E. (1970): Journal of Clinical Investigation, 49: 2097–2105.

    Article  PubMed  CAS  Google Scholar 

  83. Green, I.C. and Taylor, K.W. Diabetologia (in press).

    Google Scholar 

  84. Montague, W., Howell, S.L. and Green, I.C. Diabetologia (in press).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Pathology, Denmark Hill, SE5 8RX, London, England

    W. Montague

  2. Diabetic Department, King’s College Hospital Medical School, Denmark Hill, SE5 8RX, London, England

    W. Montague

  3. Biochemistry Group, School of Biological Sciences, University of Sussex, Brighton, BN1 9QG, Sussex, England

    I. C. Green & S. L. Howell

Authors
  1. W. Montague
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. C. Green
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. L. Howell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Montague, W., Green, I.C., Howell, S.L. (1976). Insulin Secretion — The Role and Mode of Action of Cyclic AMP. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation