The Role of Cyclic AMP in the Regulation of Glycogen Metabolism

  • Georges Van den Berghe

Abstract

The study of glycogen metabolism has probably contributed more than the investigation of any other system to the knowledge of the biological role of cAMP. The cyclic nucleotide was discovered in 1956 as a heat-stable factor mediating the action of epinephrine and glucagon on the activation of liver phosphorylase (see (1) for a review). It was the further study of phosphorylase kinase that resulted in the recognition of a cAMP dependent protein kinase (2). This finding provided a unifying concept of the mechanism of action of the cyclic nucleotide (see (3) for a review).

Keywords

Histamine Caffeine Glucocorticoid Epinephrine Catecholamine 

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Georges Van den Berghe
    • 1
    • 2
  1. 1.International Institute of Cellular and Molecular PathologyUniversité de LouvainBrusselsBelgium
  2. 2.Nationaal Fonds voor Wetenschappelijk OnderzoekBelgium

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