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Re-Examination of the Role of Cyclic AMP in the Actions of Glucagon and Epinephrine

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Abstract

The classic investigations of Sutherland and coworkers into the actions of glucagon and epinephrine on hepatic glycogenolysis led to the discovery of cyclic AMP and largely formed the basis for the second messenger hypothesis of hormone action. Figure 1 shows an early schematic representation of this hypothesis published by Sutherland and Robison in 1966. It is interesting to note that in addition to the adenylate cyclase system, the figure depicts a generalized scheme with a plasma membrane receptor X and an intracellular second messenger Y. Thus, the authors recognized the possible existence of alternative mechanisms for hormones acting through cyclic AMP.

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Authors and Affiliations

  1. Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    J. H. Exton & A. D. Cherrington

Authors
  1. J. H. Exton
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  2. A. D. Cherrington
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Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

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© 1976 Plenum Press, New York

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Exton, J.H., Cherrington, A.D. (1976). Re-Examination of the Role of Cyclic AMP in the Actions of Glucagon and Epinephrine. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_23

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  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

  • eBook Packages: Springer Book Archive

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