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Binding of Ligands to Receptors: Theory

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Eukaryotic Cell Function and Growth

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Abstract

The interaction between ligands and specific binding structures is a general problem which is encountered at different levels in the field of cyclic nucleotide metabolism and action. Some examples of ligands which interact with specific receptor sites in order to modify the activity of adenylate cyclase and other structures modulating cyclic nucleotide concentrations are listed in Table I; cyclic nucleotides exert most of their effects by interacting with specific receptor proteins : the protein kinases in eukaryotes (1) or the cAMP receptor protein in bacteria (CRP) (2).

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References

  1. CORBIN, J.D. (1975) in “Regulation of Function and Growth of Eukaryotic Cells by Intracellular Cyclic Nucleotides”, ed. J.E. Dumont, B. Brown, N. Marshall, NATO Course, Wépion, 1974 Plenum Publishing Corp., New York

    Google Scholar 

  2. DE CROMBRUGGHE, B., CHEN, B., ANDERSON, W., NISSLEY, S.P., GOTTESMAN, M., PERLMAN, R., PASTAN, I (1971), Nature New Biology, 231, 139

    PubMed  Google Scholar 

  3. BIRNBAUMER, L., POHL, S.L., Kaumann, A.J. (1974) in “Advances in Cyclic Nucleotide Research”, ed. P. Greengard, G.A. Robison, Raven Press, New York, 4

    Google Scholar 

  4. POHL, S.L., KRANS, H.M.J., BIRNBAUMER, L., RODBELL, M. (1972) J. Biol. Chem., 247, 2295

    PubMed  CAS  Google Scholar 

  5. FREYCHET, P., KAHN, R., ROTH, J., NEVILLE, D.M. (1972) J. Biol. Chem., 247, 3953

    PubMed  CAS  Google Scholar 

  6. MARX, S.J., FEDAK, S.A., AURBACH, G.D. (1972) J. Biol. Chem. 247, 6913

    PubMed  CAS  Google Scholar 

  7. CUATRECASAS, P., TELL, G.P.E., SICA, V., PARIKH, I., CHANG, K.J. (1974), Nature, 257, 92

    Article  Google Scholar 

  8. LEFKOWTIZ, R.J., SHARP, G.W.G., HABER, E (1973) J. Biol. Chem. 248, 342

    Google Scholar 

  9. BERGERON, J.J.M., EVANS, W.H., GESCHWIND, I.I. (1973), J. Cell Biol., 59, 771

    Article  PubMed  CAS  Google Scholar 

  10. SONENBERG, M. (1971), Proceed. Natl. Acad. Sci. US, 68, 1051

    Article  CAS  Google Scholar 

  11. SCHNEIDER, A.B., EDELHOCH, H. (1972) J. Biol. Chem., 247, 4986

    PubMed  CAS  Google Scholar 

  12. BIRNBAUMER, L. (1973), Biochim. Biophys. Acta, 300, 129

    PubMed  CAS  Google Scholar 

  13. PERKINS, J.P. (1973) in “Advances in Cyclic Nucleotide Research”, ed. P. Greengard, G.A. Robison, Raven Press, New York, 3

    Google Scholar 

  14. LEFKOWITZ, R.J. (1974) Biochem. Biophys. Res. Comm., 58, 1110

    Article  PubMed  CAS  Google Scholar 

  15. SINGER, S.J., NICOLSON, G.L., (1972) Science, 175, 720

    Article  PubMed  CAS  Google Scholar 

  16. BROSTROM, C.O., CORBIN, J.D., KING, C.A., KREBS, F.G. (1971) Proceed. Natl. Acad. Sci. US, 68, 2444

    Article  CAS  Google Scholar 

  17. PERKINS, J.P. MOORE, M.H. (1971), J. Biol. Chem., 246, 62

    PubMed  CAS  Google Scholar 

  18. BITENSKY, M.W., GORMAN, R.E., MILLER, W.H. (1972) Science, 175, 1363

    Article  PubMed  CAS  Google Scholar 

  19. KREINER, P.W., KEVINS, J.J. BITENSKY, M.W. (1973) Proceed. Natl. Acad. Sci. US, 70, 1785

    Article  CAS  Google Scholar 

  20. LEVEY, G.S., FLETCHER, M.A., KLEIN, I., RUIZ, E., SCHENK, A. (1974) J. Biol. Chem., 249, 2665

    PubMed  CAS  Google Scholar 

  21. MONOD, J., WYMAN, J., CHANGEUX, J.P. (1965), J. Mol. Biol., 12, 88

    Article  PubMed  CAS  Google Scholar 

  22. Koshland, D.E., Nemethy, G., Filmer, D. (1966) Biochemistry, 5, 365

    Article  PubMed  CAS  Google Scholar 

  23. BRIEHL, R.W. (1963) J. Biol. Chem., 238, 2361

    CAS  Google Scholar 

  24. CHANGEUX, J.P., THIERY, J., TUNG, Y., KITTEL, C. (1967) Proceed. Natl. Acad. Sci. US, 57, 335

    Article  CAS  Google Scholar 

  25. LEVITZKI, A., KOSHLAND, D.E., (1968) Proceed. Natl. Acad. Sci. US, 62, 1121

    Article  Google Scholar 

  26. HERZFELD, J., STANLEY, H.E. (1974), J. Mol. Biol., 82, 231

    Article  PubMed  CAS  Google Scholar 

  27. DERANLEAU, D.A. (1969), J. Am. Chem. Soc., 91, 4044

    Article  CAS  Google Scholar 

  28. HILL, A.V., (1910), J. Physiol., 40, 190

    PubMed  CAS  Google Scholar 

  29. SCATCHARD, G. (1949), Ann. N.Y. Acad. Sci., 51, 660

    Article  CAS  Google Scholar 

  30. LINEWEAVER, H., BURK, D. (1934), J. Am. Chem. Soc., 56, 658

    Article  CAS  Google Scholar 

  31. BAULIEU, E.E., RAYNAUD, J.P. (1970), Eur. J. Biochem. 13, 293

    Article  PubMed  CAS  Google Scholar 

  32. THOMPSON, C.J., KLOTZ, I.M. (1971), Arch. Biochem. Biophys., 147, 178

    Article  PubMed  CAS  Google Scholar 

  33. SWILLENS, S., VAN CAUTER, E., DUMONT, J.E. (1974), Biochim. Biophys. Acta, 364, 250

    PubMed  CAS  Google Scholar 

  34. RODBELL, M., BIRNBAUMER, L., POHL, S.L. (1969) in “The Role of Adenyl Cyclase and Cyclic 3’,5’-AMP in Biological Systems”, ed. T.W. Rail, M. Rodbell, P. Condliffe. N.I.H., Bethesda, 59

    Google Scholar 

  35. VERRIER, B., FAYET, G., LISSITZKY, S. (1974), Europ. J. Biochem. 42, 355

    Article  PubMed  CAS  Google Scholar 

  36. KONO, T., BARHAM, F.W. (1971), J. Biol. Chem., 246, 6210

    PubMed  CAS  Google Scholar 

  37. KAHN, C.R., FREYCHET, P., ROTH, J., NEVILLE, D.M. (1974) J. Biol. Chem., 249, 2249

    PubMed  CAS  Google Scholar 

  38. DE MEYTS, P., ROTH, J., NEVILLE, D.M., GAVIN, J.R., LESNIAK, M.A. (1973), Biochem. Biophys. Res. Comm., 55, 154

    Article  PubMed  Google Scholar 

  39. RODBELL, M., LIN, M.C., SALOMON, Y., (1974), J. Biol. Chem. 249, 59

    PubMed  CAS  Google Scholar 

  40. ROY, C. (1975) in “Regulation of Function and Growth of Eukaryotic Cells by Intracellular Cyclic Nucleotides”, ed. J.E. Dumont, B. Brown, N. Marshall, NATO Course, Wépion, 1974, Plenum Publishing Corp.

    Google Scholar 

  41. CUATRECASAS, P. (1971), Proceed. Natl. Acad. Sci. US, 68, 1264

    Article  CAS  Google Scholar 

  42. LEFKOWITZ, R.J., ROTH, J., PASTAN, I (1972), Ann. N.Y. Acad. Sci., 195

    Google Scholar 

  43. ROY, C., BOCKAERT, J., RAJERISON, R., JARD, S. (1973) FEBS Letters, 30, 329

    Article  PubMed  CAS  Google Scholar 

  44. LESNIAK, M.A., GORDEN, P., ROTH, J., GAVIN, J.R. (1974) J. Biol. Chem., 249, 1661

    PubMed  CAS  Google Scholar 

  45. SHLATZ, L., MARINETTI, G.V. (1972), Science, 176, 175

    Article  PubMed  CAS  Google Scholar 

  46. HAMMOND, J.M., JARETT, L., MARIZ, I.K., DAUGHADAY, W.H. (1972) Biochem. Biophys. Res. Comm. 49, 1122

    Article  PubMed  CAS  Google Scholar 

  47. POCHET, R., BOEYNAEMS, J.M., DUMONT, J.E. (1974), Biochem. Biophys. Res. Comm., 58, 446

    Article  PubMed  CAS  Google Scholar 

  48. HAYE, B., JACQUEMIN, C. (1971) FEBS Letters, 18, 47

    Article  PubMed  CAS  Google Scholar 

  49. MANLEY, S.W., BOURKE, J.R. HAWKER, R.W. (1972) J. Endocrin., 55, 555

    Article  CAS  Google Scholar 

  50. LEE, C.Y., RYAN, R.J. (1973) Biochemistry, 12, 4609

    Article  PubMed  CAS  Google Scholar 

  51. Desbuquois, B., Krug, F., Cuatrecasas, P. (1974) Biochim. Biophys. Acta. 343, 101

    Article  PubMed  CAS  Google Scholar 

  52. Cuatrecasas, P. (1974), Ann. Rev. Biochem., 43, 169

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut de Recherche Interdisciplinaire (IRIBHN), Free University of Brussels, School of Medicine, 1000, Brussels, Belgium

    J. M. Boeynaems & J. E. Dumont

Authors
  1. J. M. Boeynaems
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  2. J. E. Dumont
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Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

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© 1976 Plenum Press, New York

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Boeynaems, J.M., Dumont, J.E. (1976). Binding of Ligands to Receptors: Theory. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_2

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  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

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