Glial Transport of Amino Acid Neurotransmitter Candidates

  • Fritz A. Henn


The finding that glia had a high-affinity transport system for GABA (Henn and Hamberger, 1971), and the almost simultaneous autoradiographic confirmation of at least some glial localization for this substance in a variety of preparations (Hökfelt and Ljungdahl, 1970; Orkand and Kravitz, 1971; Neal and Iversen, 1972), suggested a closer investigation of glial transport of putative neurotransmitters. The initial studies on GABA transport were carried out using a bulk-isolated glial cell fraction obtained by the method of Bloomstrand and Hamberger (1969).


Glutamate Uptake Amino Acid Neurotransmitter Synaptosomal Fraction Taurine Uptake Central Nervous Tissue 
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  1. Benda, P., Lightbody, J., Sato, G., Levine, L., and Sweet, W., 1968, Differentiated rat glial cell strain in tissue culture, Science 161: 370–372.CrossRefGoogle Scholar
  2. Bennett, J. P., Jr., Logan, W. J., and Snyder, S. H., 1972, Amino acid neurotransmitter candidates: Sodium-dependent high affinity uptake by unique synaptosomal fractions, Science 178: 997–999.CrossRefGoogle Scholar
  3. Bloomstrand, C., and Hamberger, A., 1969, Protein turnover in cell-enriched fractions from rabbit brain, J. Neurochem. 16: 1401–1407.CrossRefGoogle Scholar
  4. Faeder, I. R., and Salpeter, M. M., 1970, Glutamate uptake by a stimulated insect nerve muscle preparation, J. Cell Biol 46: 300–307.CrossRefGoogle Scholar
  5. Henn, F. A., and Hamberger, A., 1971, Glial cell function: Uptake of transmitter substances, Proc. Natl Acad. Scl U.S.A. 68: 2686–2690.CrossRefGoogle Scholar
  6. Henn, F. A., Haljamäe, H., and Hamberger, A., 1972, Glial cell function: Active control of extracellular K+ concentration, Brain Res. 43: 437–443.CrossRefGoogle Scholar
  7. Henn, F. A., Goldstein, M. N., and Hamberger, A., 1974, Uptake of the neurotransmitter candidate glutamate by glia, Nature (London) 249: 663–664.CrossRefGoogle Scholar
  8. Hökfelt, T., and Ljungdahl, Å., 1970, Cellular localization of labeled gamma-aminobutyric Acid (3 H-GABA) in rat cerebellar cortex: An autoradiographic study, Brain Res. 22: 391–396.CrossRefGoogle Scholar
  9. Hökfelt, T., and Ljungdahl, Å., 1972, Studies of neurotransmitters at the synaptic level, Adv. Biochem. Psychopharmacol. 6: 1–36.Google Scholar
  10. Johnston, G. A. R., and Iversen, L. L., 1971, Glycine uptake in rat central nervous system slices and homogenates: Evidence for different uptake systems in spinal cord and cerebral cortex, J. Neurochem. 18: 1951–1961.CrossRefGoogle Scholar
  11. Koelle, G. B., 1955, The histochemical identification of acetylcholinesterase in cholinergic, adrenergic, and sensory neurons, J. Pharmacol Exp. Ther. 114: 167–184.Google Scholar
  12. Kuffler, S. W., and Nicholls, J. G., 1966, The physiology of neuroglial cells, Ergeb. Physiol. Biol. Chem Exp. Pharmakol. 57: 1–90.Google Scholar
  13. Logan, W. J., and Snyder, S. H., 1971, Unique high affinity uptake systems for glycine, glutamic and aspartic acids in central nervous tissue of the rat, Nature (London) 234: 297–299.CrossRefGoogle Scholar
  14. Logan, W. J., and Snyder, S. H., 1972, High affinity uptake systems for glycine, glutamic and aspartic acids in synaptosomes of rat central nervous tissues, Brain Res. 42: 413–431.CrossRefGoogle Scholar
  15. Neal, M. J., and Iversen, L. L., 1972, Autoradiographic localization of 3 H-GABA in rat retina, Nature (London) New Biol 235: 217–218.CrossRefGoogle Scholar
  16. Neal, M. J., and Pickles, H. G., 1969, Uptake of 14C-glycine by spinal cord, Nature (London) 222: 679–680.CrossRefGoogle Scholar
  17. Orkand, P. M., and Kravitz, E. A., 1971, Localization of the sites of γ-aminobutyric acid (GABA) uptake in lobster nerve-muscle preprations, J. Cell Biol 49: 75–89.CrossRefGoogle Scholar
  18. Roberts, E., and Kuriyama, K., 1968, Bio chemical-physiological correlations in studies of the γ-aminobutyric acid system, Brain Res. 8: 1–35.CrossRefGoogle Scholar
  19. Schrier, B. K., and Thompson, E. J., 1974, On the role of glial cells in the mammalian nervous system, J. Biol Chem 249: 1769–1780.Google Scholar
  20. Silbert, S. W., and Goldstein, M. N., 1972, Drug-induced differentiation of a rat glioma in vitro, Cancer Res. 32: 1422–1427.Google Scholar
  21. Wood, J. D., Watson, W. J., and Ducker, A. J., 1967, Oxygen poisoning in various mammalian species and the possible role of gamma-aminobutyric acid metabolism, J. Neurochem. 14: 1067–1074.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Fritz A. Henn
    • 1
  1. 1.Department of PsychiatryThe University of IowaIowa CityUSA

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