Functions and Development of Cell Receptors for IgE

  • Teruko Ishizaka


It has been established that IgE is present on basophil granulocytes and mast cells and that the immunoglobulin combines with these cells through the Fc portion of the molecules (1,2). Earlier studies on the cell-bound IgE was carried out in human basophil system using E myeloma protein. The isolation of rat E myeloma protein by Bazin (3) made the rat mast cell system as useful as human basophils for the studies on the mechanisms of sensitization. An advantage of the rat system is that isolation of normal rat mast cells is much easier than purification of human basophils (4). Furthermore, a basophilic leukemia cell line became available for the studies of IgE-binding (5). In this Symposium, I would like to summarize available information on cell-bound IgE and receptors on basophils and mast cells, and present our recent findings on the development of rat mast cells and their receptors by a long-term culture of thymus cells.


Mast Cell Void Volume Fraction Peritoneal Mast Cell Histamine Content Thymus Cell 
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  1. 1.
    Ishizaka, K., Tomioka, H. and Ishizaka, T., J. Immunol., 105: 1459, 1970.PubMedGoogle Scholar
  2. 2.
    Ishizaka, T., Ishizaka, K. and Tomioka, H., J. Immunol., 108: 513, 1972.PubMedGoogle Scholar
  3. 3.
    Bazin, H., Beckers, A. and Querinjean, P., Eur. J. Immunol., 4: 44, 1974.PubMedCrossRefGoogle Scholar
  4. 4.
    Bach, M.K., Bloch, K.J. and Austen, K.F., J. Exp. Med., 133: 752, 1971.PubMedCrossRefGoogle Scholar
  5. 5.
    Kulczycki, A., Jr., Isersky, C. and Metzger, H., J. Exp. Med., 139: 600, 1974.PubMedCrossRefGoogle Scholar
  6. 6.
    Ishizaka, T., Soto, C.S., and Ishizaka, K., J. Immunol., 111: 500, 1973.PubMedGoogle Scholar
  7. 7.
    Ishizaka, T. and Ishizaka, K., J. Immunol., 112: 1078, 1974.PubMedGoogle Scholar
  8. 8.
    Kulczycki, A.,Jr. and Metzger, H., J. Exp. Med., 140: 1676, 1974.CrossRefGoogle Scholar
  9. 9.
    Conrad, D.H., Bazin, H., Sehon, A.H. and Froese, A., J. Immunol., 114: 1688, 1975.PubMedGoogle Scholar
  10. 10.
    Becker, K.E., Ishizaka, T., Metzger, H., Ishizaka, K. and Grimley, P.M., J. Exp. Med., 138: 394, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Ishizaka, K. and Ishizaka, T., J. Immunol., 103: 588, 1969.PubMedGoogle Scholar
  12. 12.
    Ishizaka, T. and Ishizaka, K., Annals of the New York Academy of Sciences, 254: 462.Google Scholar
  13. 13.
    Bach, M.K. and Brashler, J.R., J. Immunol., 111: 324.Google Scholar
  14. 14.
    Konig, W. and Ishizaka, K., J. Immunol., 113: 1237, 1974.PubMedGoogle Scholar
  15. Konig, W. and Ishizaka, K., Immunochemistry - in press.Google Scholar
  16. 16.
    Conrad, D.H. and Froese, A., J. Immunol., 116: 319, 1976.PubMedGoogle Scholar
  17. 17.
    Kulczycki, A.,Jr., Siraganian, R., Mendoza, G. and Metzger, H., Fed. Proc. 34: 985, 1975.Google Scholar
  18. 18.
    Ginsburg, H. and Sachs, L., J. Nat. Cancer Institute, 31: 1, 1962.Google Scholar
  19. 19.
    Ishizaka, T., Okudaira, H., Mauser, L.E. and Ishizaka, K., J. Immunol. - in press, 1976.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Teruko Ishizaka
    • 1
  1. 1.The Johns Hopkins University School of Medicine at the Good Samaritan HospitalBaltimoreUSA

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