Functions and Development of Cell Receptors for IgE
It has been established that IgE is present on basophil granulocytes and mast cells and that the immunoglobulin combines with these cells through the Fc portion of the molecules (1,2). Earlier studies on the cell-bound IgE was carried out in human basophil system using E myeloma protein. The isolation of rat E myeloma protein by Bazin (3) made the rat mast cell system as useful as human basophils for the studies on the mechanisms of sensitization. An advantage of the rat system is that isolation of normal rat mast cells is much easier than purification of human basophils (4). Furthermore, a basophilic leukemia cell line became available for the studies of IgE-binding (5). In this Symposium, I would like to summarize available information on cell-bound IgE and receptors on basophils and mast cells, and present our recent findings on the development of rat mast cells and their receptors by a long-term culture of thymus cells.
KeywordsMast Cell Void Volume Fraction Peritoneal Mast Cell Histamine Content Thymus Cell
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- 12.Ishizaka, T. and Ishizaka, K., Annals of the New York Academy of Sciences, 254: 462.Google Scholar
- 13.Bach, M.K. and Brashler, J.R., J. Immunol., 111: 324.Google Scholar
- Konig, W. and Ishizaka, K., Immunochemistry - in press.Google Scholar
- 17.Kulczycki, A.,Jr., Siraganian, R., Mendoza, G. and Metzger, H., Fed. Proc. 34: 985, 1975.Google Scholar
- 18.Ginsburg, H. and Sachs, L., J. Nat. Cancer Institute, 31: 1, 1962.Google Scholar
- 19.Ishizaka, T., Okudaira, H., Mauser, L.E. and Ishizaka, K., J. Immunol. - in press, 1976.Google Scholar