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Production of IgE and Reaginic Antibody in Rats in Relation to Worm Infections

  • Ellen E. E. Jarrett

Abstract

Natural or experimental infection with live worm parasites is the most effective known stimulus for the production of IgE, resulting generally in higher levels of both antibody and total IgE than can be elicited by any other means. This general proposition is put into perspective by adding that virtually all animals are naturally infected with helminth parasites as are indeed the majority of human beings. Hookworm infection alone affects about 400 million people.

Keywords

Mast Cell Helminth Infection Helminth Parasite REAGINIC Antibody House Dust Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Barth, Ellen E.E., Jarrett, W.F.H. & Urquhart, G.M. (1966). Studies on the mechanism of the self-cure reaction in rats infected with N. brasiliensis. Immunology, 10, 459.Google Scholar
  2. 2.
    Bazaral, M., Orgel, Alice & Hamburger, R.N. (1973). The influence of serum IgE levels of selected recipients including patients with allergy, helminthiasis and tuberculosis on the apparent P-K titre of a reaginic serum. Clin. Exp. Immunol., 14, 117.PubMedGoogle Scholar
  3. 3.
    Bazin, H., Beckers, A., Deckers, C. & Moriame, M. (1973). Transplantable immunoglobulins secreting tumours in rats V. Monoclonal immunoglobulins secreted by 250 illeocaecal immunocytomas in Lou/W & LE rats. J. Natn. Cancer Inst., 51, 1351.Google Scholar
  4. 4.
    Bazin, H., Queringecun, P., Beckers, A., Heremans, J.F. & Dessy, F. (1974). Transplantable immunoglobulin secreting tumours in the rat IV. Sixty three IgE secreting immunocytoma tumours. Immunology, 26, 713.PubMedGoogle Scholar
  5. 5.
    Binaghi, R.A. & Benacerraf, B. (1964). The production of anaphylactic antibody in the rat. J. Immunol., 92, 920.PubMedGoogle Scholar
  6. 6.
    Bloch, K.J., Ohman, J.C., Waltin, J. & Cygan, R.W. (1973). Potentiated reagin response: initiation with minute doses of antigen and alum followed by infection with N. brasiliensis. J. Immunol., 110, 197.PubMedGoogle Scholar
  7. 7.
    Carson, D., Metzger, H. & Bloch, K.J. (1975). Serum IgE levels during the potentiated reagin response to egg-albumin in rats infected with N. brasiliensis. J. Immunol., 114, 521.PubMedGoogle Scholar
  8. 8.
    Godfrey, R.C. (1975). Asthma and IgE levels in rural and urban communities in The Gambia. Clinical Allergy, 5, 201.PubMedCrossRefGoogle Scholar
  9. 9.
    Godfrey, R.C. & Gradidge, C.F. (1976). Allergic sensitization of human lung fragments prevented by saturation of IgE binding sites. Nature, 259, 484.PubMedCrossRefGoogle Scholar
  10. 10.
    Ishizaka, Teruko, Konig, W., Kurata, M., Mauser, Linda & Ishizaka K. (1975). Immunologic properties of mast cells from rats infected with N. brasiliensis. J. Immunol., 115, 1078.PubMedGoogle Scholar
  11. 11.
    Ishizaka, Teruko, Urban, J.F. & Ishizaka, K. (1976). IgE formation in the rat following infection with N. brasiliensis. I. Proliferation and differentiation of IgE B cells. Cellular Immunology (in press).Google Scholar
  12. 12.
    Johansson, S.G.O. (1971). Personal communication.Google Scholar
  13. 13.
    Jarrett, Ellen, E.E. (1972). Potentiation of reaginic (IgE) antibody to ovalbumin in the rat following sequential trematode and nematode infections. Immunology, 22, 1099.PubMedGoogle Scholar
  14. 14.
    Jarrett, Ellen, E.E. (1973). Reaginic antibodies and helminth infection. Vet. Ree., 93, 480.CrossRefGoogle Scholar
  15. 15.
    Jarrett, Ellen & Bazin, H. (1974). Elevation of total serum IgE in rats following helminth parasite infection. Nature, 251, 613.PubMedCrossRefGoogle Scholar
  16. 16.
    Jarrett, Ellen & Ferguson, Anne (1974). Effect of T cell depletion on the potentiated reagin response. Nature, 250, 420.PubMedCrossRefGoogle Scholar
  17. 17.
    Jarrett, Ellen, E.E., Haig, D.M. & Bazin, H. (1976). Time course studies on rat IgE production in N. brasiliensis infection. Clin. Exp. Immunol., 24 (in press).Google Scholar
  18. 18.
    Jarrett, Ellen, E.E., Henderson, D., Riley, Patricia & White, R.G. (1972). The effect of various adjuvant regimens and of nematode infection on the reaginic antibody response to ovalbumin in the rat. Int. Arch. Allergy, 42, 775.PubMedCrossRefGoogle Scholar
  19. 19.
    Jarrett, Ellen, E.E., Jarrett, W.F.H. & Urquhart, G.M. (1966). Immunological unresponsiveness in adult rats to the nematode N. brasiliensis induced by infection in early life. Nature, 211, 1310.PubMedCrossRefGoogle Scholar
  20. 20.
    Jarrett, Ellen, E.E., Jarrett, W.F.H. & Urquhart, G.M. (1968). Immunological unresponsiveness to helminth parasites: I. The pattern of N. brasiliensis infection in young rats. Exp. Parasit., 23, 151.PubMedCrossRefGoogle Scholar
  21. 21.
    Jarrett, Ellen, E.E., Orr, T.S.C. & Riley, Patricia (1971). Inhibition of allergic reactions due to competition for mast cell sensitization sites by two reagins. Clin. Exp. Immunol., 9, 585.PubMedGoogle Scholar
  22. 22.
    Jarrett, Ellen, E.E. & Stewart, Diana (1972). Potentiation of rat reaginic (IgE) antibody by helminth infection. Simultaneous potentiation of separate reagins. Immunology, 23, 749.PubMedGoogle Scholar
  23. 23.
    Jarrett, Ellen, E.E. & Stewart, Diana C. (1973a). Potentiation of rat reaginic (IgE) antibody by N. brasiliensis infection. Effect of modification of life cycle of the parasite on the host. Clin. Exp. Immunol., 15, 79.PubMedGoogle Scholar
  24. 24.
    Jarrett, Ellen, E.E. & Stewart, Diana C. (1973b). The significance of circulating IgE. Correlation of amount of circulating reaginic antibody with cutaneous sensitivity in the rat. Immunology, 24, 37.PubMedGoogle Scholar
  25. 25.
    Jarrett, Ellen, E.E. & Stewart, Diana C. (1974). Rat IgE production. I. Effect of dose of antigen on primary and secondary reaginic antibody resonses. Immunology, 27, 365.PubMedGoogle Scholar
  26. 26.
    Jarrett, Ellen, E.E. & Urquhart, G.M. (1971). The immune response to nematode infection. International Review of Tropical Medicine, 453. Academic Press.Google Scholar
  27. 27.
    Kojima, S. & Ovary, Z. (1975). Effect of N. brasiliensis infection on anti-hapten IgE antibody response in the mouse. II. Mechanism of potentiation of the IgE antibody response to a heterologous hapten-carrier conjugate. Cellular Immunology, 17, 383.PubMedCrossRefGoogle Scholar
  28. 28.
    Miller, H.R.P. & Jarrett, W.F.H. (1971). Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat. Immunology, 20, 277.PubMedGoogle Scholar
  29. 29.
    Mota, I. (1964). The mechanism of anaphylaxis. I. Production and biological properties of mast cell sensitizing antibody. Immunology, 7, 681.PubMedGoogle Scholar
  30. 30.
    Murray, M. (1972). Immediate hypersensitivity effector mechanisms. II. In vivo reactions. ‘Immunity to animal parasites’. Ed. Soulsby, E.J.L. Academic Press, p.155.Google Scholar
  31. 31.
    Murray, M., Jarrett, W.F.H. & Jennings, F.W. (1971). Mast cells and the macromolecular leak in intestinal immunological reactions. Immunology, 21, 17.PubMedGoogle Scholar
  32. 32.
    Ogawa, M., Mclntyre, R., Ishizaka, K., Ishizaka, T., Terry, W.D. & Waldman, T.A. (1971). Biologic properties of E. myeloma proteins. Am. J. Med., 51, 193.PubMedCrossRefGoogle Scholar
  33. 33.
    Ogilvie, Bridget M. (1964). Reagin-like antibodies in animals immune to helminth parasites. Nature, 204, 91.PubMedCrossRefGoogle Scholar
  34. 34.
    Ogilvie, Bridget M. (1967). Reagin-like antibodies in rats infected with the nematode parasite N. brasiliensis. Immunology, 12, 113.PubMedGoogle Scholar
  35. 35.
    Ogilvie, Bridget M. & Jones, Valerie E. (1973). Immunity in the parasitic relationship between helminths and hosts. Progress in Allergy, 17, 94. S. Karger.Google Scholar
  36. 36.
    Ogilvie, Bridget M. & Hockley, D.J. (1968). Effect of immunity on N. brasiliensis adult worms: reversible and unreversible changes in infectivity reproduction and morphology. J. Parasitol., 54, 1073.PubMedCrossRefGoogle Scholar
  37. 37.
    Orr, T.S.C. & Blair, A.M.J.N. (1969). Potentiated reagin response to egg-albumin and conalbumin in N. brasiliensis infected rats. Life Sciences, 8, part II, 1073.PubMedCrossRefGoogle Scholar
  38. 38.
    Orr, T.S.C., Riley, Patricia & Doe, J.E. (1971). Potentiated reagin response to egg-albumin in N. brasiliensis infected rats. II. Time course of the reagin response. Immunology, 20, 185.PubMedGoogle Scholar
  39. 39.
    Orr, T.S.C., Riley, Patricia A. & Doe, J.E. (1972). Potentiated reagin response to egg-albumin in N. brasiliensis infected rats. III. Further studies in the time course of the reagin response. Immunology, 22, 211.PubMedGoogle Scholar
  40. 40.
    Rousseaux, R., Capron, A. & Bazin, H. (1975). Personal communication.Google Scholar
  41. 41.
    Sadun, E.H. (1972). Homocytotropic antibody response to parasitic infections. ‘Immunity to animal parasites’. Ed. Soulsby, E.J.L. Academic Press, p.97.Google Scholar
  42. 42.
    Tada, T. (1975). Regulation of reaginic antibody formation in animals. Progress in Allergy, 19, 122. S. Karger.PubMedGoogle Scholar
  43. 43.
    Urquhart, G.M., Mulligan, W., Eadie, R.M. & Jennings, F.W. (1965). Immunological studies on N. brasiliensis in the rat: The role of local anaphylaxis. Exp. Parasit., 16, 210.Google Scholar
  44. 44.
    Wilson, R.J.M. & Bloch, K.J. (1968). Homocytotropic antibody response in rats infected with the nematode N. brasiliensis J. Immunol., 100, 622.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Ellen E. E. Jarrett
    • 1
  1. 1.Veterinary Hospital, Wellcome Laboratories for Experimental ParasitologyUniversity of GlasgowBearsden, GlasgowUK

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