Skip to main content

Neutrophil Generation of Permeability Enhancing Peptides from Plasma Substrates

  • Chapter
Molecular and Biological Aspects of the Acute Allergic Reaction

Abstract

Wherever antigen-antibody complexes are deposited in tissues, there is fixation of complement, generation of chemotactic substances, accumulation of PMN-Ieukocytes, phagocytosis of the complexes by these cells, followed by release of phlogistic agents, which cause tissue injury and inflammation (Movat, 1976).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Behal, F. and folds, J.D. (1967). ‘Acrylamidase of neisseria cataralis.’ Arch.Biochem.Biophys., 121, 364.

    Article  PubMed  CAS  Google Scholar 

  • Erdös, E.G., Nakajima, T., Oshima, G., Gecse, A. and Kato, J.(1976). ‘Kininases and their interactions with other systems.’ Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease (ed. by J.J. Pisano and K.F. Austen). Fogarty International Center Proc. No. 27, U.S. Gov. Printing Office, Washington.

    Google Scholar 

  • Feinstein, G. and Janoff, A. (1975a). ‘A rapid method for purification of human granulocyte cation neutral proteases: purification and further characterization of human granulocyte elastase.’ Biophys. Biochim. Acta, 403, 493.

    CAS  Google Scholar 

  • Feinstein, G. and Janoff, A. (1975b). ‘A rapid method for purification of human granulocyte cationic neutral proteases: purification and characterization of human granulocyte chymotrypsin-like enzyme.’ Biophys.Biochim.Acta. 403, 477.

    CAS  Google Scholar 

  • Folds, J.D., Welsh, I.R.H. and Spitznagel, J.K. (1972). ‘Neutral proteases confined to one class of lysosomes of human polymorphonuclear leukocytes.’ Proc.Soc.Exp.Biol.Med., 139, 461.

    PubMed  CAS  Google Scholar 

  • Goldstein, I.M. and Weissmann, G. (1974). ‘Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leukocyte lysosomes.’ J.Immunol., 113, 1583.

    PubMed  CAS  Google Scholar 

  • Habal, F.M., Movat, H.Z. and Burrowes, C.E. (1974). ‘Isolation of two functionally different kininogens from human plasma: separation from proteinase inhibitors and interaction with plasma kallikrein.’ Biochem. Pharmacol., 23, 2291.

    Article  PubMed  CAS  Google Scholar 

  • Habal, F.M., Underdown, B.J. and Movat, H.Z. (1975). ‘Further characterization of human plasma kininogens.’ Biochem.Pharmacol., 24, 1241.

    Article  PubMed  CAS  Google Scholar 

  • Habal, F.M. and Movat, H.Z. (1976). ‘Rapid purification of high molecular weight kininogen.’ Agents and Actions, in press.

    Google Scholar 

  • Habermann, E. and Blennemann, G. (1964). ‘Über Substrate und Raktionsprodukte der kininbildenden Enzyme Trypsin, Serum-und Pankreaskallikrein sowie von Crotalusgift.’ Naunyn-Schmied.Arch. Exp.Path.Pharm., 249, 357.

    Article  CAS  Google Scholar 

  • Hedrik, J.L. and Smith, A J. (1968). ‘Size and charge isomer separation and estimation of molecular weights of proteins by disc gel electrophoresis.’ Arch.Biochem.Biophys., 126, 155.

    Article  Google Scholar 

  • Hugli, T.E., Taylor, J.C. and Crawford, I.P. (1975). ‘Selective cleavage of human C3 by human leukocyte elastase (HLE).’ Sixth International Complement Workshop, Sarasota, Florida.

    Google Scholar 

  • Janoff, A. and Scherer, J. (1968). ‘Mediators of inflammation in leukocytelysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes.’ J.Exp.Med., 128, 1137.

    Article  PubMed  CAS  Google Scholar 

  • Janoff, A. (1972). ‘Neutrophil proteases in inflammation.’ Ann.Rev.Med., 23, 177.

    Article  PubMed  CAS  Google Scholar 

  • Janoff, A. (1973). ‘Purification of human granulocyte elastase by affinity chromatography’ Lab.Invest., 29, 458.

    PubMed  CAS  Google Scholar 

  • Lazarus, G.S., Daniels, J.R., Brown, R.S., Bladen, H.Z. and Fullmer, H.M. (1968). ‘Degradation of collagen by a human granulocyte col lageno lytic system.’ J.Clin.Invest., 47, 2622.

    Article  PubMed  CAS  Google Scholar 

  • Malemud, C.J. and Janoff, A. (1975). ‘Human polymorphonuclear elastase and cathepsin G mediated the degradation of lapine articular cartilage proteoglycan.’ Ann.N.Y.Acad.Sci., 256, 254.

    Article  PubMed  CAS  Google Scholar 

  • Minta, J.O., Saya, M.J. and Movat, H.Z. (1976). ‘The generation of phlogistic fragments from C3 by a protease of human neutrophil leukocytes.’ To be published.

    Google Scholar 

  • Movat, H.Z., Steinberg, S.G., Habal, F.M. and Ranadive, N.S. (1973). ‘Demonstration of a kinin-generating enzyme in the lysosomes of human polymorphonuclear leukocytes.’ Lab.Invest., 29, 669.

    PubMed  CAS  Google Scholar 

  • Movat, H.Z. (1974). ‘Release of a kinin-forming enzyme from human polymorphonuclear leukocytes following interaction with immune complexes.’ Allergology, Proceedings of the VHIth International Congress of Allergology (ed. by Y. Yamamura). Excerpta Medica, Amsterdam.

    Google Scholar 

  • Movat, H.Z., Habal, F.M., and Macmorine, D.R.L. (1975). ‘Generation of a vasoactive peptide by a neutral protease of human neutrophil leukocytes.’ Agents and Actions, December, in press.

    Google Scholar 

  • Movat, H.Z. (1976). “Pathways to allergic inflammation: The sequelae of antigen-antibody formation.’ Symposium on Pathways to Inflammation. Fed.Proc., 35, in press.

    Google Scholar 

  • Movat, H.Z. and Habal, F.M. (1976). ‘Kininogenases of PMN-leukocyte lysosomes.’ Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease (ed. by J.J. Pisano and K.F. Austen), Fogarty International Center Proc. No. 27, U.S. Gov. Printing Office, Washington.

    Google Scholar 

  • Movat, H.Z., Habal, F.M. and Macmorine, D.R.L. (1976). ‘Neutral proteases of human PMN-leukocytes with kininogenase activity.’ Int.Arch.Allergy, 50, 257.

    Article  PubMed  CAS  Google Scholar 

  • Ohlsson, K. and Olsson, I. (1973). ‘The neutral proteases of human granulocytes. Isolation and partial characterization of two granulocyte collagenases.’ Eur.J.Biochem., 36, 473.

    Article  PubMed  CAS  Google Scholar 

  • Ohlsson, K. and Olsson, I. (1974). ‘The neutral proteases of human granulocytes. Isolation and partial characterization of granulocyte elastase.’ Eur.J.Biochem., 42, 519.

    Article  PubMed  CAS  Google Scholar 

  • Pass, E. and Movat, H.Z. (1976). ‘An aminopeptidase of human neutrophil leukocyte lysosomes.’ To be published.

    Google Scholar 

  • Reis, M.L., Okino, L. and Rocha E Silva, M. (1971). ‘Comparative pharmacological actions of bradykinin and related kinins of larger molecular weight.’ Biochem.Pharmacol., 20, 2935.

    Article  PubMed  CAS  Google Scholar 

  • Rindler-Ludwig, R. and Braunsteiner, H. (1975). ‘Cationic proteins from human neutrophil granulocytes. Evidence for their chymotrypsin- like properties.’ Biophys.Biochim.Acta, 379, 606.

    CAS  Google Scholar 

  • Sajnani, A.N., Movat, H.Z. and Ranadive, N.S. (1976). ‘Redistribution of immunoglobulin receptors on human neutrophils and its relationship to the release of lysosomal enzymes.’ Lab.Invest., in press.

    Google Scholar 

  • Saya, M.J. (1975). ‘Studies on C3: the third component of human complement.’ Dissertation, University of Toronto.

    Google Scholar 

  • Schmidt, W. and Havemann, K. (1974). ‘Isolation of elastase-like and chymotrypsin-like neutral proteases from human granulocytes.’ Hoppe-Seyler’s Z.Physiol.Chem., 335, 1077.

    Article  Google Scholar 

  • Taubman, S., Goldschmidt, P.R. and Lepow, I.H. (1970). ‘Effect of lysosomal enzymes from human leukocytes on human complement components.’ Fed.Proc., 29, 434.

    Google Scholar 

  • Taylor, J.C. and Crawford, I.P. (1975). ‘Purification and preliminary characterization of human granulocyte elastase.’ Arch.Biochem. Biophys., 169, 91.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Movat, H.Z. et al. (1976). Neutrophil Generation of Permeability Enhancing Peptides from Plasma Substrates. In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4304-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4306-6

  • Online ISBN: 978-1-4613-4304-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics