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Some Interrelations Among Chemotaxis, Lysosomal Enzyme Secretion and Phagocytosis by Neutrophils

  • Chapter
Molecular and Biological Aspects of the Acute Allergic Reaction

Abstract

A number of acute allergic responses e.g. the Arthus reaction, experimental nephrotoxic nephritis etc involve the chemotaxis, lysosomal enzyme secretion and phagocytosis of neutrophils. In these reactions, chemotactic factors liberated at the site causes infiltration of neutrophils and the secretion of lysosomal enzymes from these cells induced by actual or frustrated phagocytosis of the antigen-antibody complexes initiating the reaction induces the tissue damage (1). These functions of the neutrophil are not completely independent and unrelated. There are a number of similarities and differences in the biochemical requirements for each of these functions (2). In addition all the chemotactic factors tested, C5a, pronase sensitive and pronase insensitive fractions from E. coli culture filtrates and synthetic peptides are capable of inducing not only chemotaxis but lysosomal enzyme release (3, 4) and if these same factors are presented to the neutrophil at the same time as the particle, EAC423 they also will inhibit erythrophago- cytosis (5).

Supported by N.I.H. grant A109648 and N.I.H. contract NIDR-N-01-DE-52477.

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References

  1. Cochrane, C.G., 1968. Immunologic tissue injury mediated by neutrophilic leukocytes. Adv. Immunol. 9:97–163.

    Article  PubMed  CAS  Google Scholar 

  2. Becker, E.L. and P.M. Henson, 1973. In vitro studies of immunologically induced secretion of mediators from cells and related phenomena. Adv. Immunol. 17:93–193.

    Article  PubMed  CAS  Google Scholar 

  3. Becker, E.L., P.M. Henson, H.J. Showell and L.S. Hsu, 1974. The ability of chemotactic factors to induce lysosomal enzyme release 1. The characteristics of the release, the importance of surfaces and the relation of the release to chemotactic responsiveness. J. Immunol. 112:2047–2054.

    PubMed  CAS  Google Scholar 

  4. Goldstein, I.M., M. Brai, A.G. Osier and G. Weissmann, 1973. Lysosomal enzyme release from human leukocytes: Mediation by the alternate pathway of complement activation. J. Immunol. 109:33–37.

    Google Scholar 

  5. R. Musson and E.L. Becker, 1975. The effect of chemotactic factors on erythrophagocytosis by human neutrophils. Fed. Proceed. 34:1019.

    Google Scholar 

  6. Schiffmann, E., B.A. Corcoran and S.M. Wall, 1975. Formylmethionyl peptides as chemoattractants for leucocytes. Proc. Nat. Acad. Sci. U.S.A. 70:2916–2918.

    Google Scholar 

  7. Showell, H.J., R.J. Freer, S.H. Zigmond, E. Schiffmann, S. Aswankumar, B. Corcoran and E.L. Becker, 1976. The structure activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal enzyme secretion for neutrophils. J. Exp. Med. In press.

    Google Scholar 

  8. Becker, E.L. and H.J. Showell, 1972. Effects of Ca2+ and Mg2+ on the chemotactic responsiveness of rabbit polymorphonuclear leukocytes. Z. Immunitatsforsch. 143:466–476.

    CAS  Google Scholar 

  9. Zigmond, S.H. and J. G. Hirsch, 1973. Leukocyte locomotion and chemotaxis. New method for evaluation and demonstration of cell- derived chemotactic factor. J. Exp. Med. 137:387–410.

    Article  PubMed  CAS  Google Scholar 

  10. Schiffmann, E., H.J. Showell, B.A. Corcoran, P.A. Ward, E. Smith, and E.L. Becker, 1975. The isolation and partial characterization of neutrophil chemotactic factors from E. coli. J. Immunol. 114:831–837.

    Google Scholar 

  11. Becker, E.L., and H.J. Showell, 1974. The ability of chemotactic factors to induce lysosomal enzyme release II. The mechanism of the release. J. Immunol. 112:2055–2062.

    PubMed  CAS  Google Scholar 

  12. Zurier, R. B., S. Hoffstein and G. Weissmann, 1973. Cytochalasin B: Effect on lysosomal enzyme release from human leukocytes. Proc. Nat. Acad. Sci. U.S.A. 70:844–845.

    Article  CAS  Google Scholar 

  13. Wilkinson, P.C., 1974. Chemotaxis and Inflammation, Churchill Livingstone, Edinburgh and London.

    Google Scholar 

  14. Roberts, J. and J. H. Quastel, 1963. Particle uptake by polymorphonuclear leucocytes and Ehrlich Ascites-Carcinoma Cells. Biochem. J. 89:150–156.

    PubMed  CAS  Google Scholar 

  15. Henson, P.M., 1974. Mechanisms of activation and secretion by platelets and neutrophils. Progress in Immunology II, L. Brent and J. Holborow (Eds) North-Holland, Amsterdam-Oxford, pp. 95–105.

    Google Scholar 

  16. Showell, H.J. and Becker, E.L., 1976. The effects of external K+ and Na+ on the chemotaxis of rabbit peritoneal neutrophils. J. Immunol. 116:99–105.

    PubMed  CAS  Google Scholar 

  17. Goetzl, E. J., S. I. Wasserman, I. Gigli and K. F. Austen, 1974. Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid. J. Clin. Investig. 53: 813–818.

    Article  PubMed  CAS  Google Scholar 

  18. Baggiolini, M., J.G. Hirsch and C. de Duve, 1969. Resolution of granules from rabbit heterophil leukocytes into distinct populations by zonal sedimentation. J. Cell Biol. 40:529–541.

    Article  PubMed  CAS  Google Scholar 

  19. Goldstein, I.M., J.K. Horn, H.B. Kaplan and G. Weissmann, 1974. Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes. Biochem. Biophys. Research. Commun. 60:807–812.

    Article  CAS  Google Scholar 

  20. Hook, W.A., E. Shiffmann, S. Aswanikumar and R.P. Siraganian, 1976. Histamine release from basophils by formyl-methionine peptides. Fed. Proceed. In press.

    Google Scholar 

  21. Stossel, T.P., 1974. Phagocytosis. New Eng. J. Med. 290:717–723, 1974.

    Google Scholar 

  22. Boxer, L.A., E.T. Hedley-Whyte and T.P. Stossel, 1974. Neutrophil actin dysfunction and abnormal neutrophil behavior. New. Eng. J. Med. 291:1093–1099.

    Article  PubMed  CAS  Google Scholar 

  23. Becker, E.L., A.T. Davis, R.D. Estenson and P.G. Quie, 1972. Cytochalasin B IV Inhibition and stimulation of Chemotaxis of rabbit and human and polymorphonuclear leukocytes. J. Immunol. 108:396–402.

    PubMed  CAS  Google Scholar 

  24. Borel, J.F. and Stählein, H., 1972. Effects of cytochalasin B on Chemotaxis and immune reactions. Experentia 28:745.

    Google Scholar 

  25. Zigmond, S.H. and J.G. Hirsch, 1972. Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysis. Exp. Cell Res. 73:383–393.

    Article  PubMed  CAS  Google Scholar 

  26. Canarozzi, N.A. and S.E. Malawista, 1973. Phagocytosis of human blood leukocytes measured by the uptake of 131I-labelled human serum albumin: inhibitory and stimulatory effects of cytochalasin B. Yale J. Biol, and Med. 46:177–189.

    Google Scholar 

  27. Zurier, R.B., Hoffstein, S. and Weissmann, G., 1973. Cytochalasin B: effect on lysosomal enzyme release from human leukocytes. Proc. Nat. Acad. Sci. U.S.A. 70:844–848.

    Article  CAS  Google Scholar 

  28. Bhisey, A.N. and J.J. Freed, 1971. Altered movement of endosomes in colchicine-treated cultured macrophages. Exp. Cell Res. 64:430–438.

    Article  PubMed  CAS  Google Scholar 

  29. Allison, A.C., P. Davis and S. de Petris, 1971. Role of contractile micro-filaments in macrophage movement and endocytosis. Nature New Biol. 232:153–155.

    PubMed  CAS  Google Scholar 

  30. Bandmann, U., L. Rydgren and B. Norberg, 1974. The difference between random movement and Chemotaxis. Exp. Cell Res. 88:63–73.

    Article  PubMed  CAS  Google Scholar 

  31. Russel, R.J., P.C. Wilkinson, F. Sless and D.M.V. Parrot, 1975. Chemotaxis of lymphoblasts. Nature 256:646–648.

    Article  Google Scholar 

  32. Goldstein, I., S. Hoffstein, J. Gallin and G. Weissmann, 1973. Mechanisms of lysosomal enzyme release from human leukocytes: microtubule assembly and membrane fusion induced by a component of complement. Proc. Nat. Acad. Sci. U.S.A. 70:2916–2920.

    Article  CAS  Google Scholar 

  33. Gallin, J.I. and A.S. Rosenthal, 1974. Divalent cation requirements and calcium fluxes during human granulocyte Chemotaxis. J. Cell Biol. 62:594–606.

    Article  PubMed  CAS  Google Scholar 

  34. Ramsey, W.S. and A. Harris, 1973. Leukocyte locomotion and its inhibition by antimitotic drugs. Exp. Cell Res. 82:262–270.

    Article  PubMed  CAS  Google Scholar 

  35. Edelson, P.J. and H.F. Fudenberg, 1973. Effect of vinblastine on the chemotactic responsiveness of normal human neutrophils. Infection and Immunity 8:127–129.

    PubMed  CAS  Google Scholar 

  36. Caner, J.E., 1965. Colchicine inhibition of Chemotaxis. Arth. and Rheum. 8:757–764.

    Article  CAS  Google Scholar 

  37. Phelps, P. and D.J. McCarty, Jr., 1969. Crystal induced arthritis. Postgraduate Medicine 45:87–93.

    PubMed  CAS  Google Scholar 

  38. Ward, P.A., 1971. Leukotactic factors in health and disease. Am. J. Path. 64:521–530.

    PubMed  CAS  Google Scholar 

  39. Oliver, J.M., R.B. Zurier and R.D. Berlin, 1975. Concanavalin A cap formation on polymorphonuclear leukocytes of normal and beige (Chediak-Higashi) mice. Nature 253:471–473.

    Article  PubMed  CAS  Google Scholar 

  40. Gallin, J.I., J.S. Bujack and S. M. Wolff, 1974. Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43: 201–206.

    PubMed  CAS  Google Scholar 

  41. Clark, R.A. and H.R. Kimball, 1972. Defective granulocyte Chemotaxis in the Chediak-Higashi syndrome. J. Clin. Investig. 51:649–665.

    Article  Google Scholar 

  42. Gallin, J.I., J.A. Klimerman, G.A. Padgett and S.M. Wolff, 1975. Defective mononuclear leukocyte chemotaxis in the Chediak-Higashi syndrome of humans, mink and cattle. Blood 45:863–870.

    PubMed  CAS  Google Scholar 

  43. Weissmann, G., I. Goldstein, S. Hoffstein and P.K. Tsung, 1975. Reciprocal effects of cAMP and cGMP on microtubule-dependent release of lysosomal enzymes. Ann. N.Y. Acad. Sci. 253:750–762.

    Article  PubMed  CAS  Google Scholar 

  44. Henson, P.M, 1972. Pathologic mechanisms in neutrophil-mediated injury. Am. J. Path. 68:593–612.

    PubMed  CAS  Google Scholar 

  45. Hawkins, D., 1972. Inhibition of neutrophil lysosomal release Fed. Proceed 31:748.

    Google Scholar 

  46. Hoffstein, S., 1975. Microtubule assembly and secretion in human polymorphonuclear leukocytes. Fed. Proceed 34:868.

    Google Scholar 

  47. Stoseel, T.P., R.K. Root and M. Vaughn 1972. Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. New. Eng. J. Med. 286:120–123.

    Article  Google Scholar 

  48. Malawista, S.E., 1975. Action of colchicine in acute gouty arthritis. Arth. Rheum 18:835–846.

    Article  CAS  Google Scholar 

  49. Lehrer, R.I., 1973. Effects of colchicine and chloramphemicol on the oxidative metabolism and phagocytic activity of human neutrophils. J. Infect. Dis. 127:40–48.

    Article  PubMed  CAS  Google Scholar 

  50. Stossel, T.P., R.J. Mason, J. Hartwig and M. Vaughn, 1972. Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J. Clin. Investig. 51:615–625.

    Article  PubMed  CAS  Google Scholar 

  51. Griffin, F.M. Jr., J.A. Griffin, J.E. Leider and S.C. Silverstein, 1975. Studies on the mechanism of phagocytosis 1. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane. J. Exp. Med. 142:1263–1282.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Connecticut Health Center, 06032, Farmington, CT, USA

    Elmer L. Becker

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Editors and Affiliations

  1. University Hospital, Uppsala, Sweden

    S. G. O. Johansson

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Strandberg  & Börje Uvnäs  & 

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© 1976 Plenum Press, New York

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Becker, E.L. (1976). Some Interrelations Among Chemotaxis, Lysosomal Enzyme Secretion and Phagocytosis by Neutrophils. In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_18

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  • DOI: https://doi.org/10.1007/978-1-4613-4304-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4306-6

  • Online ISBN: 978-1-4613-4304-2

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