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Prostaglandins and Related Substances in Acute Allergic Reactions

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Molecular and Biological Aspects of the Acute Allergic Reaction

Abstract

The prostaglandins (PGs) constitute an ever growing family of naturally occurring biologically active carbon 20 unsaturated fatty acids which are synthetized in practically all mammalian tissues studied. They are rapidly deactivated by metabolism in most tissues and there is evicence to suggest that their possible physiological significance is related to local formation and action rather than to a hormone function proper (Piper and Vane 1971). Increased PG formation has been demonstrated in conjunction with a number of physiological and pathophysiological processes, e.g. hormone and nervous activity, smooth muscle contraction, inflammation and hypersensitivity reactions (c.f. Piper and Vane 1971, Vane 1974).

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References

  • Cuthbert, M. F.: Bronchodilator activity of aerosols of prostaglandins E1 and E2 in asthmatic subjects. Proc. R. Soc. Med. 64: 15–16, 1971.

    PubMed  CAS  Google Scholar 

  • Cuthbert, M. F.: Prostaglandins and respiratory smooth muscle. In: The Prostaglandins [Cuthbert, M.F. et al., ed.] Philadelphia, J.B. Lippincott Co., pp. 253–285, 1973.

    Google Scholar 

  • Dunlop, L. S. and Smith, A. P.: Reduction of antigen-induced contraction of sensitized human bronchi in vitro by indomethacin. Br. J. Pharmac. 54: 495–497, 1975.

    CAS  Google Scholar 

  • Green, K., Hedqvist, P. and Svanborg, N.: Increased plasma levels of 15-keto, 13,14-dihydro PGF2α after allergen-provoked asthma in man. Lancet, 2: 1419–1421, 1975.

    Google Scholar 

  • Hamberg, M., Svensson, J. and Samuelsson, B.: Novel transformations of prostaglandin endoperoxides: Formation of thromboxanes. In Advances in Prostaglandin and Thromboxane Research [Samuelsson, B. and Paoletti, R., eds.]. Raven Press, New York, in press.

    Google Scholar 

  • Hamberg, M., Hedqvist, P., Strandberg, K., Svensson, J. and Samuelsson, B.: Prostaglandin endoperoxides IV. Effects on smooth muscle. Life Sci. 16: 451–462, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Hamberg, M. and Samuelsson, B.: Detection and isolation of an endo-peroxide intermediate in prostaglandin biosynthesis. Proc. Nat. Acad. Sci. USA 70: 899–903, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Hamberg, M. and Samuelsson, B.: Novel transformations of arachidonic acid in guinea-pig lung. Biochem. Biophys. Res. Commun. 61: 942–949, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Hamberg, M. and Svensson, J.: Biosynthesis and metabolism of prostaglandin endoperoxides and thromboxanes in platelets. Proc. of an International Symposium on Platelets and Thrombosis. Academic Press 1976.

    Google Scholar 

  • Hamberg, M., Svensson, J., Hedqvist, P., Strandberg, K. and Samuelsson, B.: Involvement of the endoperoxide system in anaphylactic reactions. In Advances in Prostaglandin and Thromboxane Research (Samuelsson, B. and Paoletti, R., eds.). Raven Press, New York, in press.

    Google Scholar 

  • Hamberg, M., Svenssgn, J., Wakabayashi, T. and Samuelsson, B.: Isolation and structure of two prostaglandin endoperoxides which cause platelet aggregation. Proc. Nat. Acad. Sci. USA 71: 345–349, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Horton, E. W.: Hypotheses on physiological roles of prostaglandins. Physiol. Rev. 49: 122–166, 1969.

    PubMed  CAS  Google Scholar 

  • Hägermark, Ö. and Strandberg, K.: Pruritogenic activity of prostaglandin E2 Acta dermatovenereol. (Stockholm), in press.

    Google Scholar 

  • Kaliner, M. and Austen, K. F.: Cyclic AMP, ATP and reversed anaphylactic histamine release from rat mast cells. J. Immunol. 112: 664–674, 1974.

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L. M. and Bourne, H. R.: Inhibition of allergic histamine release by histamine and other agents which stimulate adenyl cyclase. In Biochemistry of the Acute Allergic Reactions (Austen, K. F. and Becker, E. L., eds.) Oxford, Blackwell Sci. Publ., pp. 161–174, 1971.

    Google Scholar 

  • Liebig, R., Bernauer, W. and Peskar, B. A.: Release of prostaglandins, a prostaglandin metabolite, slow reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines. Naunyn Schmiedeberg’s Arch. Pharmacol. 284: 279–293, 1974.

    Article  CAS  Google Scholar 

  • Mathe, A. A. and Hedqvist, P.: Effect of prostaglandins F2 and E2 on airway conductance in healthy subjects and asthmatic patients. Amer. Rev. Resp. Pis. 111: 313–320, 1975.

    CAS  Google Scholar 

  • Mathe, A. A., Hedqvist, P., Holmgren, A. and Svanborg, N.: Bronchial hypereactivity to prostaglandin F2α.and histamine in patients with asthma. Br. Med. J. 1: 193–196, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Mathe, A. A. and Levine, L.: Release of prostaglandins and metabolites from guinea-pig lung: Inhibition by catecholamines. Prostaglandins 4: 877–890, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Okazaki, T., Vervloet, D., Attallah, A., Lee, J. B. and Arbesman, C. E.: Prostaglandins and asthma: The use of blood components for metabolic studies. J. Allergy Clin. Immunol. 57: 124–133, 1975.

    Article  Google Scholar 

  • Orange, R. P., Kaliner, M. A., Laraia, P. J. and Austen, K. F.: The immunological release of histamine ad slow reacting substance of anaphylaxis from human lung. II. Influence of cellular levels of cyclic AMP. Fed. Proc. 30: 1725–1729, 1971.

    PubMed  CAS  Google Scholar 

  • Orehek, J., Douglas, J. S., Lewis, A. J. and Bouhuys, A.: Prostaglandin regulation of airway smooth muscle tone. Nature New Biol. 245: 84–85, 1973.

    PubMed  CAS  Google Scholar 

  • Piper, P. J.: Distribution and metabolism. In The Prostaglandins [Cuthbert, M.F., ed.] Philadelphia, J.B. Lippincott Co., pp. 125–150, 1973.

    Google Scholar 

  • Piper, P. J. and Walker, J. L.: The Release of spasmogenic substances from human chopped lung tissue and its inhibition. Br. J. Pharmac. 47: 291–304, 1973.

    CAS  Google Scholar 

  • Piper, P. J. and Vane, J. R.: Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature 223: 29–35, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Piper, P. J. and Vane, J. R.: The release of prostaglandin from lung and other tissues. Ann. N.Y. Acad. Sci. 180: 363–383, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Snith, A. P. and Dunlop, L.: Prostaglandins and asthma. Lancet 1: 39, 1975.

    Article  Google Scholar 

  • Snith, N. J. H. and Dawkins, P. D.: Salicylates and enzymes. J. Pharm. Pharmacol. 23: 729–744, 1971.

    Article  Google Scholar 

  • Strandberg, K. and Hamberg, M.: Increased excretion of 5,7-dihydro-11-keto-tetranor-prostanoic acid on anaphylaxis in the guinea-pig. Prostaglandins 6: 159–170, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Strandberg, K. and Hedqvist, P.: Bronchial effects of some prostaglandin E1, E2 and F2α analogues. Acta physiol. scand., in press.

    Google Scholar 

  • Svanborg, N., Hedqvist, P. and Green, K.: Aspects on prostaglandin action in asthma. In Advances in Prostaglandin and Thromboxane Research Samuelsson, B. and Paoletti, R., eds. Raven Press, New York, in press.

    Google Scholar 

  • Söndergaard, J. and Greaves, M. W.: Recovery of a pharmacologically active fatty acid during the inflammatory reaction, invoked by patch testing in allergic contact ekzema. Int. Arch. Allerg. 39: 56–61, 1970.

    Article  PubMed  Google Scholar 

  • Tauber, A. I., Kaliner, N., Stechschulte, D. J. and Austen, K. F.: Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung: V. Effects of prostaglandins. J. Immunol. 111: 27–32, 1973.

    PubMed  CAS  Google Scholar 

  • Tuvemo, T., Strandberg, K., Hamberg, M. and Samuelsson, B.: Formation and action of prostaglandin endoperoxides in the isolated human umbilical artery. Acta physiol. scand., in press.

    Google Scholar 

  • Walker, J. L.: The regulatory function of prostaglandins in the release of histamine and SRS-A from passively sensitized human lung tissue. In Advances in the Biosciences. International Conference on Prostaglandins. Pergamon Press. Vieweg, pp. 235–240, 1973.

    Google Scholar 

  • Vane, J. R.: The contribution of prostaglandins and other mediators to the allergic state. In Allergy’74. Proc. Ninth Europ. Congr. Allergol. Clin. Immunol. [Sanderton, M. A. and Frankland, A.W., eds.] Pitruan Medical Publ. Co. Kent, pp. 79–92, 1974.

    Google Scholar 

  • Vargaftig, B. B., DE Miranda, E. P. and Lacoume, B.: Inhibition by non-steroidal anti-inflammatory agents of in vivo effects of slow reacting substance C. Nature 222: 883–885, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Weissman, G., Goldstein, I. and Hoffstein, S.: Prostaglandins and the modulation by cyclic nucleotides of lysosomal enzyme release. In Advances in Prostaglandin and Thromboxane Research. [Samuelsson, B. and Paoletti, R., eds.], Raven Press, New York, in press.

    Google Scholar 

  • Yen, S., Sohn, R. J., Mathe, A. A., Strandberg, K. and Cochin, J.: Release of prostaglandins from the guinea-pig lung. Fed. Proc, 35: 458, 1976.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Karolinska institutet, S-104 01, Stockholm 60, Sweden

    Kjell Strandberg

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  1. Kjell Strandberg
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Editors and Affiliations

  1. University Hospital, Uppsala, Sweden

    S. G. O. Johansson

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Strandberg  & Börje Uvnäs  & 

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© 1976 Plenum Press, New York

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Strandberg, K. (1976). Prostaglandins and Related Substances in Acute Allergic Reactions. In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_16

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  • DOI: https://doi.org/10.1007/978-1-4613-4304-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4306-6

  • Online ISBN: 978-1-4613-4304-2

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