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Abstract

Most if not all the known actions of cyclic nucleotides are mediated over protein kinases (1). In view of the recent data implicating cyclic AMP and cyclic GMP as modulators or even mediators of histamine release frcm mast cells (2) it was of interest to examine the mast cell protein kinases. The following is a brief report of our preliminary findings.

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References

  1. Langan, T.A.: Protein kinases and protein kinase substrates. Adv. Cyclic Nucleotide Res. 3: 99–153, 1973.

    PubMed  CAS  Google Scholar 

  2. Parker, C.W., T.J. Sullivan and H.J. Wsdner: Cyclic AMP and the inmunic response. Adv. Cyclic Nucleotides Res. 4: 1–79, 1974.

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  3. Walsh, D.A., C.D. Ashby, C. Gonzales, D. Calkius, E.H. Fischer and E.G. Krebs: Purification and characterization of a protein inhibitor of adenosine 3’,5’-monophosphate-dependent protein kinases. J. Biol. Chem. 246: 1977–1985, 1971.

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  4. Kuo, J.F.: Divergent actions of protein kinase modulator in regulating mammalian cyclic GMP-dependent and cyclic AMP-dependent protein kinases. Metabolism. 24: 321–329, 1975.

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© 1976 Plenum Press, New York

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Fredholm, B.B., Uvnäs, B. (1976). Discussion Remark: Protein Kinases in Rat Mast Cells. In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_11

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  • DOI: https://doi.org/10.1007/978-1-4613-4304-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4306-6

  • Online ISBN: 978-1-4613-4304-2

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