Advertisement

Modes of Action of Antigen-Antibody Reaction and Compound 48/80 in Histamine Release

  • Börje Uvnäs

Abstract

There is general agreement today about the mast cell being a secretory cell. It reacts to a multitude of agents with the release not only of histamine and heparin but of a whole battery of biologically active materials, either preformed and stored in the basophil granules or formed during the secretory process. The mast cells are the specific target cells for allergens because of the very high affinity of their cell membrane for IgE globulins. These IgE molecules, are assumed to act as specific receptors for circulating allergens. The mast cell response to other “releasing” or “degranulating” agents is also supposed to require an attachment of these agents to specific receptors on the mast cell surface. These receptors are so far not identified. The attachment to the receptor is assumed to be the crucial step in the activation of the mast cell response, initiating a series of biochemical events ending with exocytosis, partial degranulation and the release of biologically active materials.

Keywords

Mast Cell Histamine Release Acta Physiol Mast Cell Granule Induce Histamine Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Foreman, J.C., Mongar, J.L., Gomperts, B.D., Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature, 245, 249–251, 1973.PubMedCrossRefGoogle Scholar
  2. 2.
    Kanoe, T., Cochrane, D.E., Douglas, W.W., Exocytosis (secretory granule extension) induced by injection of calcium into mast cells. Can. J. Physiol. Pharmacol. 51, 1001–1004, 1973.CrossRefGoogle Scholar
  3. 3.
    Högberg, B. and Uvnäs, B., The mechanism of the disruption of mast cells produced by ccmpound 48/80. Acta physiol. scand. 41, 345–369, 1957.PubMedCrossRefGoogle Scholar
  4. 4.
    Becker, E.L. and Austen, K.F., Mechanism of immunologic injury of rat peritoneal mast cells. I. The effect of phosphonate inhibitors on the homocytotrophic antibody-mediated histamine release and the first component of the rat complement. J. Exp. Med. 124, 379–396, 1966.PubMedCrossRefGoogle Scholar
  5. 5.
    Ranadive, N.S., Cochrane, C.G., Mechanism of histamine release from mast cells by cationic protein (band 2) from neutrophil lysosomes. J. Immunol. 100, 506–516, 1971.Google Scholar
  6. 6.
    Kaliner, M. and Austen, K.F., Cyclic nucleotides and modulation of effector systems of inflammation. Biochem. Pharmacol. 23, 763–771, 1974.PubMedCrossRefGoogle Scholar
  7. 7.
    Sullivan, T.J., Parker, K.L., Stenson, W., Parker, C.W., Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic and physical stimuli. J. Immunol. 114, 1473–1479, 1975.PubMedGoogle Scholar
  8. 8.
    Sullivan, T.J., Parker, K.L., Eisen, S.A., Parker, C.W., Modulation of cyclic AMP in purified mast cells. II. Studies on the relationship between intracellular cyclic AMP concentrations and histamine release. J. Immunol. 114, 1480–1485, 1975.PubMedGoogle Scholar
  9. 9.
    Fredholm, B.B., Gushin, I., Elwin, K., Schwab, G. and Uvnäs, B., Cyclic AMP independent inhibition by papaverine of histamine release induced by compound 48/80. Biochem. Pharmacol. 25, 1976 (in press).Google Scholar
  10. 10.
    Röhlich, P., Anderson, P., Uvnäs, B., Electron microscope observations on compound 48/80-induced degranulation in rat mast cells. Evidence for sequential exocytosis of storage granules. J. Cell Biol. 51, 465–483, 1971.PubMedCrossRefGoogle Scholar
  11. 11.
    Anderson, p., Slorach, S.A., Uvnäs, B., Sequential exocytosis of storage granules during antigen-induced histamine release frcm sensitized rat mast cells in vitro. An electron microscopic study. Acta physiol. scand. 96, 512–525, 1976.Google Scholar
  12. 12.
    Samuelsson, O., Ion exchangers in analytical chemistry. Almqvist & Wiksell, Stockholm 1972.Google Scholar
  13. 13.
    Uvnäs, B. and Åborg, C.-H., An in vitro-formed protamine-hepa- rin complex as a model for a two-compartment store for biogenic amines. Acta physiol. scand. 96, 512–525, 1976.PubMedCrossRefGoogle Scholar
  14. 14.
    Bergendorff, A., Uvnäs, B., Storage properties of rat mast cell granules in vitro. Acta physiol. scand. 87, 213–222, 1973.PubMedCrossRefGoogle Scholar
  15. 15.
    Austen, K.F., Biochemical characteristics and pharmacological modulation of the antigen-induced release of the chemical mediators of immediate hypersensitivity. In: Allergology. Proceedings of the VIII International Congress of Allergology. Tokyo, October 14–20, 1973. Eds. Y. Yamamura et al. Excerpta Medica. 1974. American Elsevier Publishing Co. Inc., New York, pp. 306–315.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Börje Uvnäs
    • 1
  1. 1.Department of PharmacologyKarolinska institutetStockholmSweden

Personalised recommendations