Modes of Action of Antigen-Antibody Reaction and Compound 48/80 in Histamine Release

  • Börje Uvnäs


There is general agreement today about the mast cell being a secretory cell. It reacts to a multitude of agents with the release not only of histamine and heparin but of a whole battery of biologically active materials, either preformed and stored in the basophil granules or formed during the secretory process. The mast cells are the specific target cells for allergens because of the very high affinity of their cell membrane for IgE globulins. These IgE molecules, are assumed to act as specific receptors for circulating allergens. The mast cell response to other “releasing” or “degranulating” agents is also supposed to require an attachment of these agents to specific receptors on the mast cell surface. These receptors are so far not identified. The attachment to the receptor is assumed to be the crucial step in the activation of the mast cell response, initiating a series of biochemical events ending with exocytosis, partial degranulation and the release of biologically active materials.


Mast Cell Histamine Release Acta Physiol Mast Cell Granule Induce Histamine Release 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Börje Uvnäs
    • 1
  1. 1.Department of PharmacologyKarolinska institutetStockholmSweden

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