Abstract
Massive doses of vitamin D3 or of 25 hydroxyvitamin-D3 (250H-D3) are necessary to raise the serum calcium of patients with hypoparathyroidism (1). Recent data obtained by Kooch and al. (2) have indicated an impaired conversion of 25OH-D3 into lα, 25 dihydro xyvitamin-D3 (lα, 25(OH)2-D3) in patients with hypoparathyroidism and pseudohypoparathyroidism. On the basis of the above data we have attempted to test the therapeutic effect of physiologic doses of lα-hydroxyvitamin-D3 (lα-0H-D3) in 2 patients with post-surgical hypoparathyroidism.
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References
Pak, C.Y.C., DeLuca, H.F., Chvez de los Rios, J.M. et al: Treatment of vitamin D-resistant hypoparathyroidism with 25-hydroxycholecalciferol. Arch. Intern. Med. 126, 239–247, 1970.
Kooh, S.W., Fraser, D., DeLuca, H.F. et al: Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabolites of vitamin D; evidence for impaired conversion of 25-hydroxy-vitamin D to 1α, 25-dihydroxyvitamin D. N. Engl. J. Med. 293, 840–844, 1975.
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© 1976 Plenum Press, New York
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Jelonek, A.S., Lorenc, R.S., Sliwowski, A., Grochowski, J. (1976). Therapeutcial Effect of 1α-Hydroxyvitamin-D3 in Patients with Hypoparathyroidism after Throidectomy. In: Fleisch, H., Robertson, W.G., Smith, L.H., Vahlensieck, W. (eds) Urolithiasis Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4295-3_92
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DOI: https://doi.org/10.1007/978-1-4613-4295-3_92
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