Comparison of Quantitative Element Distribution in Kidney and Muscle Tissue of Patients with Calcium Oxalate Calculi
It is desirable that as many elements as possible should be determined simultaneously because it is not known at first which concentration will be out of range.
Samples will have to be small, because preferably tissue of living patients should be studied. In case of death deviations from the living pattern cannot be ruled out.
As complex biological systems are involved, due to which element concentrations in healthy people show natural fluctuations, only investigations of a large number of samples will lead to conclusive results. This in turn requires a widely automated analytical method.