Demonstration of Protective (Inhibitory) Effects of Urinary Macromolecules on the Crystallization of Calcium Oxalate

  • W. B. Gill
  • J. W. Karesh


Several inhibitors of kidney stone salt crystallization have been found to be effective in human urine which has led to the hypothesis that kidney stones may be caused by a deficiency of inhibitors in an otherwise normal supersaturated urine. Several small molecular weight (<1000) inhibitors of calcium oxalate and/or calcium phosphate crystallization have been reported 1 2 3. In a comparison of human urinary retentates with their dialysates, our laboratory has previously found a significant inhibition of the crystallization of urinary calcium oxalate by urinary macromolecules (UMM).4


Crystallization Rate Calcium Oxalate Small Molecular Weight Artificial Urine Supersaturation Level 
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    Thomas, W.C. Inhibitors of Mineralization & Renal Stones p141 Nordin, B. Churchill Publ., London IbidGoogle Scholar
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    Gill, W.B. and Roma, M.J. Determinants of Supersaturation Levels and Crystallization Rates of Calcium Oxalate from Urines of Normal Humans & Stone-Formers: Effects of Non-Dialyzable Materials. Presented 7th Ann. Meeting Assoc. Academic Surgery, Nov., 1973, Rochester, N.Y. (in press) J. Surgical Research.Google Scholar
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  6. 6.
    Gill, W.B., Silvert, M.A. and Roma, M.J. Supersaturation Levels & Crystallization Rates from Urines of Normal Humans and Stone-Formers Determined by a 14C-Oxalate Technique. J. Invest. Urol. 12:203, 1974.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. B. Gill
    • 1
  • J. W. Karesh
    • 1
  1. 1.The University of ChicagoChicagoUSA

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