Abstract
Several inhibitors of kidney stone salt crystallization have been found to be effective in human urine which has led to the hypothesis that kidney stones may be caused by a deficiency of inhibitors in an otherwise normal supersaturated urine. Several small molecular weight (<1000) inhibitors of calcium oxalate and/or calcium phosphate crystallization have been reported 1 2 3. In a comparison of human urinary retentates with their dialysates, our laboratory has previously found a significant inhibition of the crystallization of urinary calcium oxalate by urinary macromolecules (UMM).4
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Russell, R.G. and Fleisch, H. Pyrophosphate and Stone Formation p. 165 in Renal Stone Research Symposium, Leeds, 1968. Ed. Hodgkinson, P. and Nordin, B. Churchill Publ., London.
Thomas, W.C. Inhibitors of Mineralization & Renal Stones p141 Nordin, B. Churchill Publ., London Ibid
Sutor, D.J. Growth Studies of Calcium Oxalate in the Presence of Various Ions and Compounds. I Brit. J. Urol. 4l:171, 1969, II Brit. J. Urol. 42:296, 1970.
Gill, W.B. and Roma, M.J. Determinants of Supersaturation Levels and Crystallization Rates of Calcium Oxalate from Urines of Normal Humans & Stone-Formers: Effects of Non-Dialyzable Materials. Presented 7th Ann. Meeting Assoc. Academic Surgery, Nov., 1973, Rochester, N.Y. (in press) J. Surgical Research.
Gill, W.B. and Karesh, J.W. A Crystallization Profile of Urinary Calcium Oxalate (Supersaturation Levels, Crystallization Rates, Metastable Limits and Heterogeneous Nucleation). Presented at the Int. Colloq. Renal Lithiasis. Jan., 1975 U. of Fla. (in press).
Gill, W.B., Silvert, M.A. and Roma, M.J. Supersaturation Levels & Crystallization Rates from Urines of Normal Humans and Stone-Formers Determined by a 14C-Oxalate Technique. J. Invest. Urol. 12:203, 1974.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Gill, W.B., Karesh, J.W. (1976). Demonstration of Protective (Inhibitory) Effects of Urinary Macromolecules on the Crystallization of Calcium Oxalate. In: Fleisch, H., Robertson, W.G., Smith, L.H., Vahlensieck, W. (eds) Urolithiasis Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4295-3_29
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4295-3_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4297-7
Online ISBN: 978-1-4613-4295-3
eBook Packages: Springer Book Archive