Abstract
The term “idiopathic” renal lithiasis refers to the various types of stones formed in the kidney for which there is no clearly identifiable cause. Recent advances in renal stone research, particularly in the clarification of pathogenetic mechanisms, have provided improved definition and necessitated reclassification of causes for Ca stones. The purpose of this discussion is to review our own scheme for classification of Ca urolithiasis, and to consider new developments in pathophysiology, diagnosis, and management.
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References
Koch, J., Stokstad, E.L.R., Williams, H.E. and Smith, L.H., Jr.: Deficiency of 2-oxo-glutarate:glyoxylate carboligase activity in primary hyperoxaluria. Proc. Nat. Acad. Sci. 57: 1123, 1967.
Williams, H.E. and Smith, L.H., Jr.: L-glyceric aciduria. A new genetic variant of primary hyperoxaluria. New Engl. J. Med. 278: 233, 1968.
Dowling, R.H., Rose, G.A. and Sutor, D.J.: Hyperoxaluria and renal calculi in ileal disease. Lancet 1:1103, 1971.
Chadwick, V.S., Modha, K. and Dowling, R.H.: Mechanism for hyperoxaluria in patients with ileal dysfunction. New Engl. J. Med. 289: 172, 1973.
Smith, L.H., Fromm, H. and Hofmann, A.F.: Acquired hyperoxaluria, nephrolithiasis, and intestinal disease; description of a syndrome. New Engl. J. Med. 286: 1371, 1972.
Coe, F.L. and Kavalach, A.G.: Hypercalciuria and hyperuricosuria in patients with calcium nephrolithiasis. New Engl. J. Med. 291:1344, 1974.
Pak, C.Y.C. and Holt, K.: Nucleation and growth of brushite and calcium oxalate in urine of stone-formers. Metab. In press.
Pak, C.Y.C., Ohata, M., Lawrence, E.C. and Snyder, W.: The hypercalciurias: causes, parathyroid functions and diagnostic criteria. J. Clin. Invest. 54:387, 1974.
Pak, C.Y.C., Kaplan, R.A., Townsend, J. and Waters, O.: A simple test for the diagnosis of absorptive, resorptive, and renal hypercalciurias. New Engl. J. Med. 292:497, 1975.
Nordin, B.E.C., Peacock, M. and Wilkinson, R.: Hypercalciuria and calcium stone disease. In: Clinics in Endocrinology and Metabolism. Vol. 1, No. 1. I. McIntyre, ed. W. B. Saunders Company, Philadelphia, p. 169, 1972.
Coe, F.L., Canterbury, J.M., Firpo, J.J. and Reiss, E.: Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. J. Clin. Invest. 52:134, 1973.
Pak, C.Y.C., Barilla, D., Bone, H. and Northcutt, C.: Medical management of renal calculi. Symposium on Advances in Endocrinology and Metabolism. Hahnemann Medical College & Hospital of Philadelphia, Philadelphia, Pa., 1976. In press.
Coe, F.L. and Raisen, L.: Allopurinol treatment of uric-acid disorders in calcium-stone formers. Lancet 1: 129, 1973.
Kaplan, R.A., Haussier, M. and Pak, C.Y.C.: In preparation.
Haussler, M.R., Bursac, K.M., Bone, H. and Pak, C.Y.C.: Increased circulating lα,25-dihydroxyvitamin D3 in patients with primary hyperparathyroidism. Clin. Res. 23: 322A, 1975.
Coe, F.L., Lawton, R.L., Goldstein, R.B. and Tembe, V.: Sodium urate accelerates precipitation of calcium oxalate in vitro. Proc. Soc. Exp. Biol. Med. 149:926, 1975.
Pak, C.Y.C. and Arnold, L.H.: Heterogeneous nucleation of calcium oxalate by seeds of monosodium urate. Proc. Soc. Exp. Biol. Med. 149: 930, 1975.
Finlayson, B. and Smith, A.: Stability of first dissociable photon of uric acid. J. Chem. Engineer. Data 19:94, 1974.
Pak, C.Y.C.: Sodium cellulose phosphate: Mechanism of action and effect on mineral metabolism. J. Clin. Pharm. 13:15, 1973.
Hayashi, Y., Kaplan, R.A. and Pak, C.Y.C.,: Effect of sodium cellulose phosphate therapy on crystallization of calcium oxalate in urine. Metab. 24:1273, 1975.
Pak, C.Y.C.: Effects of cellulose phosphate and of sodium phosphate on the formation product and activity product of brushite in urine. Metab. 21:447, 1972.
Fleisch, H., Bisaz, S. and Care, A.D.: Effect of orthophosphate on urinary pyrophosphate excretion and the prevention of urolithiasis. Lancet 1:1065, 1964.
Smith, L.H., Thomas, W.C., Jr. and Arnaud, C.D.: Orthophosphate therapy in calcium renal lithiasis. In: Urinary Calculi. International Symposium Renal Stone Research, Madrid, 188–197. Karger, Basel 1973.
Shen, F., Baylink, D., Nielson, R., Hughes, M. and Haussler, M.: Increased serum 1, 25-dihydroxycholecalciferol (1, 25-di-OHD3) in patients with idiopathic hypercalciuria (IH). Clin. Res. 23:423A, 1975.
Ohata, M. and Pak, C.Y.C.: The effect of diphosphonate on calcium phosphate crystallization in urine in vitro. Kidn. Intern. 4:401, 1973.
Pak, C.Y.C., Ohata, M. and Holt, K.: Effect of diphosphonate on crystallization of calcium oxalate in vitro. Kidn. Intern. 7:154, 1975.
Pak, C.Y.C.: Physicochemical and clinical aspects of nephrolithiasis. International Colloquium on Renal Lithiasis. January 24–26, University of Florida, Gainesville, Florida, 1976. In press.
Ohata, M. and Pak, C.Y.C.: Preliminary study of the treatment of nephrolithiasis (calcium stones) with diphosphonate. Metab. 23:1167, 1974.
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Pak, C.Y.C. (1976). Idiopathic Renal Lithiasis: New Developments in Evaluation and Treatment. In: Fleisch, H., Robertson, W.G., Smith, L.H., Vahlensieck, W. (eds) Urolithiasis Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4295-3_17
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DOI: https://doi.org/10.1007/978-1-4613-4295-3_17
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