The Effect of Delta-9-Tetrahydrocannabinol on Intraocular Pressure in Humans
One of the physiologic effects of marihuana, which was noted as early as 1971, is its ability to lower intraocular pressure (Hepler and Frank, 1971). This has been documented in at least one controlled study in human subjects with normal intraocular pressures (Hepler, Frank and Ungerleider, 1972). In addition, Purnell and Gregg (1975) at the University of North Carolina have reported a decrease in intraocular pressure in two subjects when given intravenous delta-9-tetrahydrocannabinol, the active component of marihuana. The purpose of this study is to describe further the effects of intravenous delta-9-tetrahydrocannabinol on intraocular pressure in subjects with normal intraocular pressures.
KeywordsPlacebo Permeability Catheter Phenol Depression
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