The Effect of Delta-9-Tetrahydrocannabinol on Intraocular Pressure in Humans

  • Paul Cooler
  • John M. Gregg


One of the physiologic effects of marihuana, which was noted as early as 1971, is its ability to lower intraocular pressure (Hepler and Frank, 1971). This has been documented in at least one controlled study in human subjects with normal intraocular pressures (Hepler, Frank and Ungerleider, 1972). In addition, Purnell and Gregg (1975) at the University of North Carolina have reported a decrease in intraocular pressure in two subjects when given intravenous delta-9-tetrahydrocannabinol, the active component of marihuana. The purpose of this study is to describe further the effects of intravenous delta-9-tetrahydrocannabinol on intraocular pressure in subjects with normal intraocular pressures.


Human Serum Albumin Intraocular Pressure Minnesota Multiphasic Personality Inventory Marijuana Smoking Perception Distortion 
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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Paul Cooler
    • 1
    • 2
  • John M. Gregg
    • 3
  1. 1.Department of OphthalmologyUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.McPherson HospitalDurhamUSA
  3. 3.Department of Oral SurgeryUniversity of North Carolina School of MedicineChapel HillUSA

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